Nikki H. Stricker, Ph.D., L.P., investigates cognitive changes in aging and neurodegenerative disease. Her primary research interests include identification of early cognitive markers of Alzheimer's disease and other neurodegenerative disorders, computerized cognitive assessment, diagnostic accuracy of neuropsychological tests, and cognition as an outcome measure in clinical trials.
- Can cognitive measures predict who will develop Alzheimer's disease? Dr. Stricker is working to determine whether traditional neuropsychological tests and computerized cognitive assessment can detect subtle cognitive decline in people who are otherwise cognitively normal. Her research will help determine whether these subtle changes can predict the biomarker status of cognitively normal individuals, future cognitive decline, and eventual diagnosis of mild cognitive impairment or dementia. This work may help identify individuals with the earliest stages of Alzheimer's disease who might be eligible for early interventions with therapies.
- Diagnostic accuracy and normative data. Dr. Stricker is also working to enhance the diagnostic accuracy of neuropsychological measures for detection of individuals with subtle cognitive decline, mild cognitive impairment (MCI) and dementia. Dr. Stricker is updating normative data for neuropsychological tests and determining what inclusion criteria for normative data yield the most sensitive and specific diagnostic classifications.
Significance to patient care
Dr. Stricker's research will help evaluate the utility of neuropsychological measures in the detection of preclinical Alzheimer's disease and in the clinical diagnosis of MCI and dementia. This will contribute to our ability to identify early diagnostic and prognostic indicators for Alzheimer's disease and other dementias, help identify who may benefit most from early intervention, and aid prevention efforts.
- Recipient, Research Grant, Alzheimer's Association, 2018-2021
- Recipient, Robert A. and Phyllis Levitt Early Career Award in Neuropsychology (Division 40), American Psychological Association, Society for Clinical Neuropsychology, 2018
- Education Advisory Committee Member, Society for Clinical Neuropsychology (Division 40), American Psychological Association, 2014-2017
- Recipient, Mentored Career Development Award, VA New England Veterans Integrated Service Network, 2013-2015
- Editorial Board Member, Journal of the International Neuropsychological Society, 2011-2013
- Recipient, New Investigator Award in Alzheimer's Disease, Funded by The Rosalinde and Arthur Gilbert Foundation, American Federation for Aging Research, 2010-2013