Rochester, Minnesota




Brian Patrick O'Neill, M.D., has accumulated more than 40 years of experience as a translational brain tumor investigator. This extensive clinical, research, education and administrative expertise undergirds his service on research activities going forward.

During his research career at Mayo Clinic, Dr. O'Neill has served as:

  • The founder of the Mayo Clinic Comprehensive Cancer Center Translational Research Program in Neuro-Oncology, now the Neuro-Oncology Program. He led the program for over three consecutive National Cancer Institute (NCI)-funding periods.
  • An NCI-funded investigator for clinical trials on nervous system malignancies.
  • The principal investigator for Mayo Clinic Brain Cancer Specialized Program of Research Excellence and director of its Administrative Core over two consecutive funding periods.

An emeritus professor of neurology with Mayo Clinic College of Medicine and Science, Dr. O'Neill is currently working as a supplemental research consultant with an active translational research program. Also, he is continuing his work as corresponding program director and principal investigator for an NCI Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant in brain cancer research.

Focus areas

  • Primary brain tumors
  • Metastatic brain tumors
  • Neurologic complications of cancer
  • Brain tumor epidemiology
  • Postgraduate brain tumor training and education

Significance to patient care

Dr. O'Neill is focusing on providing postgraduate brain tumor training and education. His efforts to develop and sustain the next wave of brain tumor investigators will advance brain tumor research and improve future treatments and patient care.


Primary Appointment

  1. Enterprise Medical Sub-Specialty Director, Division of Neuro-Oncology, Department of Neurology

Administrative Appointment

  1. Emeritus, Department of Neurology
  2. Supplemental, Department of Neurology

Academic Rank

  1. Professor of Neurology


  1. Research Associate - Experimental Neuropathology University of Virginia School of Medicine
  2. Resident - Neurology University of Virginia Hospitals
  3. Fellow - Neuropathology National Hospital for Nervous Disorders
  4. Resident - Internal Medicine Emory University Hospital
  5. MD State University of New York - College of Medicine, Syracuse
  6. Summer Intern New York State Department of Health
  7. BS Siena College

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