Clinical Disorders

These multidisciplinary research teams are focused on the diagnosis and treatment of psychiatric and psychological disorders. Areas of focus include mood disorders, anxiety disorders, obesity and eating disorders, addictions, and psychosomatic disorders.

Depression and bipolar disorder

The Mayo Clinic Depression Center conducts clinically relevant research in treatment-resistant depression and bipolar disorder. Current research projects aim to build on the comprehensive and multidisciplinary treatment programs offered at our center. The center also collaborates with the National Network of Depression Centers.




Mayo Clinic's neuromodulation research group investigates the uses of electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) in the treatment of mood disorders. Functional neuromodulation, such as DBS, offers opportunity for surgical treatment of refractory psychiatric disorders. TMS is a novel, noninvasive intervention that is effective in treating depression. In addition, the research group performs large multicenter trials of ECT efficacy and methods to prevent patient relapse after ECT treatment.

Pediatric anxiety disorders

The goal of this multidisciplinary research group is to improve the care of children and adolescents with anxiety disorders, including obsessive-compulsive disorder (OCD).

The team has developed Mayo Clinic Anxiety Coach, an iPhone application for anxiety management in children. Other projects include evaluating the relative effectiveness of different components of cognitive behavioral therapy (CBT), examining treatments at the health system level, investigating the relationship between anxiety symptoms and social adjustment, and developing intensive treatments for pediatric anxiety disorders.

Pediatric psychology research

The pediatric psychology research team works with health care providers across Mayo Clinic to support children and their families by initiating new behavioral treatments for young patients with both acute and chronic medical or psychological conditions.

Wellness coaching and resiliency

Mayo Clinic has developed several programs, such as the Mayo Clinic Healthy Living Program, that are designed to enhance the lifestyle of trainees, employees, patients and caregivers.