Infectious Diseases Research

Below are current clinical trials.

203 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Early Identification of Pulmonary Coccidioidomycosis

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to identify, recruit, and enroll patients with community-acquired pneumonia (CAP) to collect their blood, sputum, urine, and a nasopharyngeal swab for specimen storage. The study also aims to develop a biomarker assay to detect circulating antigen in patients infected with Coccidioides.

2. A Study To Evaluate The Effectiveness And Safety Of An Amikacin Liposome Inhalation Suspension-based Regimen In Adults With Nontuberculous Mycobacterial Lung Infection

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate the effectiveness of ALIS + azithromycin (AZI) + ethambutol (ETH) compared to the empty liposome control (ELC) + AZI + ETH on patient reported respiratory symptoms at Month 13.

3. Registry Of Patients Treated With Systemic Mold-Active Triazoles

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to describe representative real-world patterns of care for the management of invasive fungal infections (IFIs), including invasive mold infection (IMI). Specifically, the study goals are to examine real world patient characteristics and treatment patterns, associated healthcare resource utilization, and outcomes associated with use of mold-active triazoles (MATs) to treat invasive fungal infections (IFIs).

4. Characterizing HIV-related Diastolic Dysfunction

   Rochester, Minn.

   The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.

    

    

5. Healthy Immigrant Families: Working Together To Move More and To Eat Well

   Rochester, Minn.

   This project will broadly explore the efficacy of community participation in the design and implementation of an intervention to improve physical activity and nutrition among immigrant and refugee (Hispanic, Somali, Sudanese, Cambodian) families in Rochester, Minnesota

6. A Study To Collect Blood Samples To Study Immune Response Genes That May Be Associated With An Increased Risk Of Severe Influenza

   Rochester, Minn.

   The purpose of this study is to obtain a whole blood sample from which DNA will be extracted to study polymorphisms in immune response genes and other geneticvariants that may be associated with an increased risk of disease progression among individuals with infectious diseases of public health importance who are enrolled in qualifying INSIGHT studies.

7. Microbiota Restoration Therapy for Recurrent Clostridium Difficile-associated Diarrhea

   Scottsdale/Phoenix, Ariz.

   This study will assess the safety of a new biologic drug, RBX2660 (microbiota suspension) as a treatment for recurrent Clostridium difficile-associated diarrhea (CDAD), which is the primary symptom of recurrent Clostridium difficile infection. All eligible subjects will receive RBX2660.

8. A Study to Evaluate a Real-Time Diagnostic Platform for the Detection of Influenza Strains in Saliva

   Rochester, Minn.

   The purpose of this study is to develop a colorimetric test for influenza virus detection in a chemically engineered cup/tube. When sample fluid (saliva) is in the tube, the fluid color turning blue indicates a positive result. We are in the process of developing this test, and will test on saliva samples from flu patients.

9. A Study to Improve Treatment of Clostridium Difficile Infection and using Information Technology to Improve the Care of Patients with Severe Clostridium Difficile Infection

   Rochester, Minn.

   The purpose of the study is to ascertain the efficacy of implementation of standard treatment guidelines for the treatment of C. difficile infection based on disease severity and number of instances of this infection.

10. A Study To Evaluate The Efficacy, Safety, And Pharmacokinetics Of Co-Administration Of ABT-493 And ABT-530 With And Without RBV In Subjects With Chronic Hepatitis C Virus (HCV) Genotypes 2, 3, 4, 5 Or 6 Infection

    Scottsdale/Phoenix, Ariz.

    The purpose of this study is to evaluate the safety and efficacy of ABT-493 and ABT-530 (or ABT-493/ABT-530) coadministered with and without ribavirin in adults with chronic HCV genotypes 2, 3, 4, 5 or 6 infection. In part 4, the primary objectives also include to assess the efficacy (SVR12) of treatment with ABT-493/ABT-530 combination regimen in GT2-infected DAA-naive subjects without cirrhosis compared to historical SVR12 rate of treatment with sofosbuvir plus RBV in GT2-infected DAA-naive subjects without cirrhosis.