Infectious Diseases Research

Below are current clinical trials.

227 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Testing of Real-Time Diagnostic Platform (HPView) for the Detection of High-risk HPV Strains in Urine

   Rochester, Minn.

   The purpose of this study is to test whether our developed real-time HPV detection platform (HPView) performs at a comparable level to the clinical gold-standard.

2. A Study to Evaluate Positive SARS-CoV-2 Antibodies in Subjects with Bipolar Disorder

   Rochester, Minn.

   The purpose of this study is to evaluate the clinical and neurocognitive correlates of COVID-19 in patients with bipolar disorder (BD). 

3. Genetic Expression in Osteolysis, Infection, Arthrofibrosis & Metal Reactions in THA & TKA: A Microarray Analysis to Characterize Individual Host Response to the Molecular Mechanisms of Loosening and Arthrofibrosis

   Rochester, Minn.

   This study is being conducted to determine gene and protein expression profiles (i.e. which genes and proteins are turned off and on) of those with a possibility of developing osteolysis, infection, arthrofibrosis or metallosis of their THA/TKA.

4. A Study to Evaluate the Effectiveness of Vacuum-Assisted Dressings for the Management of Open Chest Wounds

   Jacksonville, Fla.

   The purpose of this study is to evaluate the effectiveness of Vacuum-assisted dressings for treating patients who have open chest wounds by comparing the time-to-closure of such wounds to traditional wound care management.

5. Laboratory Assay Optimization 2.0

   Rochester, Minn.

   The purpose of this study is to better understand the role of HIV and/or HCV infection and/or SARS-CoV-2 on the immune system and potential ways to eliminate the virus(es).

6. A Study To Evaluate At Home Administration Of Pertuzumab Combined With Trastuzumab To Treat Patients With HER2-Positive Breast Cancer During COVID-19 Pandemic

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to assess the safety of PH FDC SC when administered at home by an HHNP. Patients will be assessed for safety by regular evaluation of AEs, vital signs, routine clinical laboratory tests (hematology, blood chemistry), LVEF assessments, and by physical examinations.

7. Benznidazole For Treatment Of Chagas Disease (American Trypanosomiasis)

   Scottsdale/Phoenix, Ariz.

   The objective of the treatment program described here is to make benznidazole available in the United States on a compassionate-use basis for treatment of T. cruzi infection—specifically, for patients who have acute or congenital infection, reactivated infection, or chronic infection (without advanced cardiac disease)—and for prophylaxis of infection, when indicated in the setting of proven exposure. Benznidazole will be provided for individual patients who meet the eligibility criteria, on request of the treating physician, after consultation with CDC staff.

8. Pathogen Identification In Pediatric Hematopoietic Stem Cell Transplant Patients With Suspected Lower Respiratory Tract Infection

   Rochester, Minn.

   This is a multicenter prospective collection of leftover respiratory tract secretions, paired blood and NP swabs, and clinical circumstances from pediatric HCT patients, followed by next generation genomic sequencing, transcriptome analysis, protein biomarker measurement, and statistical modeling.

9. A Study Using VE303 To Prevent Recurrence Of Clostridium Difficile Infection

   Rochester, Minn.

   The purpose of this study will evaluate the safety and effectiveness of VE303 for participants with recurrent Clostridium difficile infection (rCDI).

10. A Study To Assess The Safety, Tolerability And Effectiveness Of Monoclonal Antibodies To Treat Hospitalized Patients With COVID-19

    Rochester, Minn.

    The purpose of this study is to evaluate the effectiveness, safety, and tolerability of REGN10933+REGN10987 in hospitalized adult patients with COVID-19.