Infectious Diseases Research

Below are current clinical trials.

203 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Dissecting the Genetic Environment Contributions of Autoimmune Liver Disease

   Rochester, Minn.

   The overall objective of this proposal is to conduct a systematic approach to dissect both genetic underpinnings and non-genetic factors in the development of adult autoimmune liver diseases including autoimmune hepatitis (AIH), overlap AIH with Primary Biliary Cirrhosis (AIH-PBC), overlap AIH with Primary Sclerosing Cholangitis (AIH-PSC), and drug-induced autoimmune-like hepatitis (DIAIH).

2. A Study Comparing Measurements of Response to Antiviral Treatments for Liver Transplant Patients that have Recurrent Hepatitis C

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to measure the rates of continuing viral presence, following anti-viral therapy with combined Peg-Interferon and Ribavirin in patients that have had a liver transplant, are immune suppressed with Neoral or tacrolimus, and have a recurring infection with the Hepatitis C virus.

3. A Study To Evaluate The Safety And Efficacy Of Ombitasvir/ABT-450/Ritonavir And Dasabuvir In Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection And Cirrhosis

   Scottsdale/Phoenix, Ariz.

   A Study to Evaluate the Safety and Efficacy of Ombitasvir/ABT-450/Ritonavir and Dasabuvir in Adults with Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis.

4. A Study To Evaluate The Efficacy And Safety Of A Vaccine, ASP0113, In Cytomegalovirus (CMV)-Seronegative Kidney Transplant Recipients Receiving An Organ From A CMV-Seropositive Donor

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the efficacy of ASP0113 compared to placebo in reducing the incidence of cytomegalovirus (CMV) viremia in CMV-seronegative subjects receiving a kidney from a CMV-seropositive donor. This study will also evaluate the safety of ASP0113 in this patient population.

5. A Randomized, Double-Blind, Multicenter, Phase 3 Study Of The Efficacy, Safety, And Tolerability Of Brincidofovir Versus Valganciclovir For The Prevention Of Cytomegalovirus Disease In CMV Seronegative Kidney Allograft Recipients

   Rochester, Minn.

   To compare the efficacy of brincidofovir (BCV) to valganciclovir (vGCV) for the prevention of cytomegalovirus (CMV) disease in kidney transplant allograft recipients who are CMV seronegative pretransplant and received a kidney from a CMV seropositive donor.

6. A Study to Compare Saliva and Swab Specimens in Detection of COVID Severe Acute Respiratory Syndrome

   Rochester, Minn.

   Compare Patient-Collected Saliva and Health Care Worker Collected Nasopharyngeal and Nasal Mid-Turbinate Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Detection by nucleic acid amplification testing (NAAT). All tests will be performed using previously-validated, EUA NAATs that are available in the Clinical Microbiology laboratory, including the Mayo Clinic laboratory developed test (LDT).

    

    

    

    

7. Comparison of Respiratory Pathogen Detection in Upper Versus Lower Respiratory Tract Samples using the Biofire Filmarray Respiratory Panel

   Rochester, Minn.

   The purpose of this study is to compare the performance of the FilmArray Respiratory Panel in nasopharyngeal (NP) swabs and bronchoalveolar lavage (BAL) fluid collected from immunocompromised hosts (ICH).

8. A Study to Evaluate the Outcome of Patients with Prosthetic Joint Infection

   Rochester, Minn.

   The purpose of this study is to assess the outcome of prosthetic joint infection (PJI) treated with various therapeutic regimens using a prospective cohort study.

9. A Study to Evaluate the Relationship Between Vaginal and Lower Urinary Tract Microbiomes and Infection After A Hysterectomy

   Rochester, Minn.

   The purpose of this study is to learn more about the microbes (bacteria) that live in the vagina and the bladder. The investigators are doing this research study to understand the relationship between microbes (the microbiome) and the occurrence of urinary tract infection following surgical removal of the uterus and pelvic organ prolapse repair.

10. A Study to Evaluate Rapid Throughput Screening for Human COVID-19 Infection

    Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

    The purpose of this study is to determine the safety and feasibility of the POC AI-ECG’s ability to detect active SARS-Cov-2 infection in humans, and to determine specificity, sensitivity, and diagnostic accuracy of POC AI-ECG’s detection of human with COVID-19 when compared to a PCR test.