Nuclear Magnetic Resonance Specialties

The Mayo Clinic Metabolomics Core provides powerful nuclear magnetic resonance (NMR) tools to help researchers clarify the structure of unknown compounds, conduct in vivo experiments and measure metabolite kinetics in isotope tracing studies.

NMR microscopy

• In vivo murine microscopy from head to tail — including brain, heart, liver, kidney and more — with T1, T2, T2* weighting, DTI, DWI, SWI, perfusion, angiography, cholangiography, functional imaging, cine cardiac imaging and spectroscopic imaging
• NMR microscopy of fresh, fixed, formalin-fixed paraffin-embedded tissue: T1, T2, T2* weighting, DTI, DWI and SWI

NMR spectroscopy

• 600, 700 MHz: 1D, 2D, 3D homo- and heteronuclear spectroscopy of biological macromolecules (proteins, DNA, RNA)
• 500, 600, 700 MHz: 1D, 2D, 3D homo- and heteronuclear NMR spectroscopy of body fluids and tissue extracts
• 500, 600, 700 MHz: 1D, 2D ¹H/¹³C NMR of small organic molecules
• 300, 700 MHz: in vivo ¹H, ³¹P localized NMR spectroscopy of small murine specimens