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Single And Multiple Dose Escalation Of PHIN-214 In Child-Pugh A And B Liver Cirrhotics
Rochester, MN
The purpose of this study is to establish the Maximum Tolerated Dose (MTD), assess the safety, tolerability, and pharmacokinetics of subcutaneous PHIN-214 in participants with compensated and decompensated cirrhosis. In addition, various exploratory markers of effectiveness will be analyzed.
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Study Evaluating The Safety And Efficacy Of Semaglutide, And The Fixed-Dose Combination Of Cilofexor And Firsocostat, Alone And In Combination, In Participants With Compensated Cirrhosis (F4) Due To Nonalcoholic Steatohepatitis (NASH)
Rochester, MN
The primary objective of this study is to evaluate whether the combination of semaglutide (SEMA) with the fixed-dose combination (FDC) of cilofexor/firsocostat (CILO/FIR) causes fibrosis improvement and Nonalcoholic Steatohepatitis (NASH) resolution in participants with compensated cirrhosis due to NASH.
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A Study To Evaluate The Combining Of Endoscopic Ultrasound Guided Liver Biopsy And Stomach Balloon Placement For The Diagnosis And Management Of Nonalcoholic Fatty Liver Disease And Obesity
Rochester, MN
The purpose of this study is to evaluate the usefulness of combining a core liver biopsy guided by endoscopic ultrasound and stomach balloon placement by endoscope for the diagnosis and treatment of fatty liver disease and obesity.
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A Study to Evaluate Diagnostic Accuracy of the Controlled Attenuation Parameter(CAP) Measured by FibroScan® in Patients Scheduled for a Liver Biopsy
Rochester, MN
We purpose of this study is to evaluate the diagnosis accuracy of the Controlled Attenuation Parameter (CAP) measured by FibroScan® (both with M and XL probes) in all patients who are undergoing liver biopsy for any liver disease.
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A Study of Improving Liver Ultrasound Effectiveness for Fibrosis Staging
Rochester, MN
The purpose of this study is to assess the effectiveness of a new ultrasound technique for non-invasive evaluation of liver fibrosis.
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A Study Of Senseera Liquid Biopsy In Detecting ACR
Jacksonville, FL
The purpose of the study is to optimize and validate the performance of the Senseera liquid biopsy cfChIP-seq assay for the detection of Acute Cellular Rejection (ACR) of the liver in patients who underwent a liver graft, as compared to the standard of care biopsy of the liver and histopathological examination by specialized pathologists.
The sensitivity and specificity of the test will be compared to the reference standard, based on the biopsy results, and the overall diagnostic accuracy of the assay will be assessed.
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Usefulness of Controlled Attenuation Parameter (CAP) for the Assessment of Liver Steatosis
Rochester, MN
The primary aim of this study is to determine the accuracy of CAP from Fibroscan in the quantification of liver steatosis in donors using liver biopsies as the gold standard.
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Correlation of Hepatic MR Elastography with Histopathology and/or Abdominal MRI in Patients with Chronic Liver Disease and Malignancy
Scottsdale/Phoenix, AZ
The purpose of this study is to compare the accuracy of non-invasive MRE (Magnetic Resonance Elastography) with the results of liver biopsy and/or MRI (Magnetic Resonance Imaging).
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Aggressive Malignancy PDX (Avatar) and Cryopreservation Program
Rochester, MN
The purpose of this study is to assess the ability to successfully create numerous validated patient-derived xenograft (PDX) models from patient tumor specimens obtained at surgery/biopsy via the new Pathology/TRAG cryopreservation protocol, and to generate a large catalog and repertoire of previously unavailable histologically validated PDX.