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Describes the nature of a clinical study. Types include:
The purpose of this study is to gather information regarding the use of rTMS as a treatment for depression in adolescents with Major Depressive Disorder. The investigators also hope to learn if measures of brain activity (cortical excitability and inhibition) collected with transcranial magnetic stimulation (TMS) can be used to identify which patients will benefit from certain types of rTMS treatment.
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The purpose of this study is to to use functional imaging to study the mechanisms of anterior thalamic nucleus (ANT) Deep Brain Stimulation (DBS).
The purpose of this study is to track seizure occurrence, seizure probability, behavioral state, cognition, and mood using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S & PAD) provides intracranial EEG (iEEG) sensing, electrical brain stimulation, and machine learning algorithms running on the RC+S and PAD that will be coupled with electrical brain stimulation (EBS) to prevent seizures and improve quality of life in patients with epilepsy
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up in different geographic populations.
The purpose of this study is to investigate the feasibility and safety of thalamic CL stimulation in restoring consciousness in epilepsy patients.
The aim of this feasibility study is to investigate whether we can improve sleep quality in patients who have DBS devices implanted for existing neurological indications by delivering targeted stimulation patterns during specific stages of sleep using their existing DBS device. We will only use electrical stimulation frequencies that have been proven to be safe for patients. We will perform these studies in patients admitted to the hospital in order to examine the structure and quality of sleep as well as how alert patients are when they wake up, while also monitoring physiological markers such as brainwave activity, heart rate and blood pressure. Upon awakening, we will ask the patients to provide their subjective opinion of their sleep and complete some simple tests to see how alert they are compared to a night of no electrical stimulation.
We hope that our study will open new ways of optimizing sleep in patients with neurological disease who are implanted with DBS device. We also believe tha tour findings will broaden the understanding of how the activity of deep brain areas influences sleep and alertness.
The purpose of this study is to test different stimulation parameter sets and evaluate patient outcomes.
The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.
The overall purpose of this study is to evaluate the effectiveness and safety of brain stimulation techniques currently used for clinical patient care. To determine the likelihood of improvements in seizure frequency, neurological symptoms, and quality of life after treatment with brain stimulation in certain populations, as well as evaluate for any beneficial or deleterious side effects from these modalities. In addition, in instances were brain stimulation was used for diagnostic purposes such as with cortical mapping via TMS, outcomes will be compared to other results already available in the electronic medical record system (e.g., MRI).
The primary purpose of this study is to map the electrophysiological properties of deep brain stimulation (DBS) targets and associated areas by analyzing signals recorded for clinical purposes. Electrophysiological properties such as spike statistics, power spectral density, spike-field coupling, and phase-amplitude coupling may be correlated to anatomic structures. An atlas with these properties could improve DBS lead targeting.
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