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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 11 for Osteoarthritis

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  1. A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty

    Jacksonville, FL

  2. RCT Comparing Robotically-Assisted vs. Manually-Executed Total Knee Arthroplasties

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  3. Autologous Culture Expanded Adipose Derived MSCs for Treatment of Painful Hip OA

    Rochester, MN

  4. A Study to Evaluate Comprehensive Arthroscopic Management (CAM) Procedure with Bone Marrow Aspirate Concentrate (BMAC) for Shoulder Osteoarthritis (OA)

    Jacksonville, FL

  5. A Study to Analyze Surgical Outcomes and Predictors of Treatment for Hip Diseases

    Rochester, MN

  6. A Study of the Safety and Usability of Culture Expanded STEM Cells Derived from the Patient's Own Fat Tissue for Treatment of Knee Osteoarthritis

    Rochester, MN

  7. A Study to Evaluate the Safety and Feasibility of Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Fraction (SVF) for Treatment of Osteoarthritis of the Knee

    Jacksonville, FL

  8. Genetic Expression in Osteolysis, Infection, Arthrofibrosis & Metal Reactions in THA & TKA: A Microarray Analysis to Characterize Individual Host Response to the Molecular Mechanisms of Loosening and Arthrofibrosis

    Rochester, MN

  9. A Study to Assess Pre- and Postoperative Serum Mast Cell Tryptase Levels in Primary TKA Patients to Determine Whether There is an Association with the Development of Post-operative Stiffness

    Rochester, MN

  10. A Study to Assess Wrist Range of Motion via Telemedicine

    Jacksonville, FL

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