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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Cancer-related only

Search Results 1-10 of 11 for Liver transplant

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  • Study status: Open/Status Unknown
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  1. Cell-Mediated Immunity Based Primary Prophylaxis for CMV Infection in Organ Transplant Recipients

    Rochester, MN

    Cell-Mediated Immunity Based Primary Prophylaxis for CMV Infection in Organ Transplant Recipients

    • Location:

      Interventional

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    • Study phase:

      III
      During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

    About this study

    The study will prospectively determine the clinical utility of CMV cell-mediated immunity using the Quantiferon test. The investigators will use the assay results to tailor the duration of CMV prophylaxis in solid organ transplant patients.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Contact us for the latest status

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    • Site IRB:

      • Rochester, Minnesota: 15-009199

    • NCT ID:

      NCT02784756

    • Sponsor Protocol Number:

      UHN-TID-003

  2. Hydroxocobalamin as a New and Possibly Superior Treatment for Refractory Vasoplegic Syndrome during Liver Transplant Surgery

    Jacksonville, FL

    Hydroxocobalamin as a New and Possibly Superior Treatment for Refractory Vasoplegic Syndrome during Liver Transplant Surgery

    • Location:

      Interventional

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.

     

     

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Jacksonville, Fla.

    Open for enrollment

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    • Site IRB:

      • Jacksonville, Florida: 18-006247

    • NCT ID:

      NCT04054999

    • Sponsor Protocol Number:

      18-006247

  3. A Study to Evaluate Clinical Performance of the Aptima® CMV Quant Assay on the Panther® System

    Rochester, MN

    A Study to Evaluate Clinical Performance of the Aptima® CMV Quant Assay on the Panther® System

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to evaluate the clinical performance of the Aptima CMV Quant assay on the Panther system in ethylenediaminetetraacetic acid (EDTA) plasma samples from solid organ transplantation recipients (SOTR) and hematopoietic stem cell transplant recipients (HSCTR).

     

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

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    • Site IRB:

      • Rochester, Minnesota: 19-001676

    • Sponsor Protocol Number:

      19-001676

  4. A Study to Learn More About Children Before and After Liver Transplant

    Rochester, MN

    A Study to Learn More About Children Before and After Liver Transplant

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to gather information that may improve the medical care of children who need or who have had liver transplants.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Contact us for the latest status

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    • Site IRB:

      • Rochester, Minnesota: 13-009794

    • Sponsor Protocol Number:

      SRN-1001

  5. A Study to Better Understand Why Patients Gain Weight After Undergoing Liver Transplantation

    Rochester, MN

    A Study to Better Understand Why Patients Gain Weight After Undergoing Liver Transplantation

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to understanding the mechanisms of weight gain in patients following liver transplantation, action, and indicate approaches to prevent weight gain.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

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    • Site IRB:

      • Rochester, Minnesota: 17-010550

    • Sponsor Protocol Number:

      17-010550

  6. Metabolomics of Portal Venous Blood for the Study of the Gut-liver Axis in Hepatobiliary Disease

    Rochester, MN

    Metabolomics of Portal Venous Blood for the Study of the Gut-liver Axis in Hepatobiliary Disease

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to determine if there are differences in the metabolites (enzymes and other proteins) found in portal venous blood (blood in the portal vein, which delivers blood from the intestines to the liver), peripheral venous blood, and bile between individuals with liver disease undergoing liver transplantation and healthy donors. With this information, we may be able to better understand the importance and nature of the relationship between the gut (i.e. intestines) and the liver in the context of liver disease and identify pathways which may lead to the development of new and improved therapies for patients with liver disease. 

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

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    • Site IRB:

      • Rochester, Minnesota: 13-001312

    • Sponsor Protocol Number:

      13-001312

  7. A Study Looking at the Impact of Gabriel House of Care (a Hospital Hospitality House, HHH) on the Quality of Life and Mood of Liver Transplant Patients

    Jacksonville, FL

    A Study Looking at the Impact of Gabriel House of Care (a Hospital Hospitality House, HHH) on the Quality of Life and Mood of Liver Transplant Patients

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The aim of this study is to measure the differences in quality of life and mood of liver transplant recipients in the immediate month post- transplant staying at the Gabriel House of Care staying at a hotel, apartment or rental property. 

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Jacksonville, Fla.

    Contact us for the latest status

    		View complete study & contact information
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    • Site IRB:

      • Jacksonville, Florida: 16-007743

    • Sponsor Protocol Number:

      16-007743

  8. A Pilot Study Examining Thiamine Deficiency in Patients Admitted to the Hospital for Liver Transplantation

    Jacksonville, FL

    A Pilot Study Examining Thiamine Deficiency in Patients Admitted to the Hospital for Liver Transplantation

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to report the proportion of thiamine deficiency (as defined by the Mayo Clinic Laboratory reference range) in liver transplant patients.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Jacksonville, Fla.

    Open for enrollment

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    • Site IRB:

      • Jacksonville, Florida: 18-010361

    • Sponsor Protocol Number:

      18-010361

  9. A Study to Measure the Circulating Tumor Cells in the Blood of the Portal and Hepatic Veins of the Liver During the Transplant Surgery of Patients with Liver Cancer

    Rochester, MN

    A Study to Measure the Circulating Tumor Cells in the Blood of the Portal and Hepatic Veins of the Liver During the Transplant Surgery of Patients with Liver Cancer

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to investigate means to identify circulating tumor cells from the portal vein and hepatic vein blood of patients with liver cancer at the time of liver transplantation.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

    		View complete study & contact information
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    • Site IRB:

      • Rochester, Minnesota: 16-002423

    • Sponsor Protocol Number:

      16-002423

  10. A Study to Compare Medical and Non-Medical Coping on Functional Outcomes and Caregiver Burden Among Liver Transplant Patients

    Jacksonville, FL

    A Study to Compare Medical and Non-Medical Coping on Functional Outcomes and Caregiver Burden Among Liver Transplant Patients

    • Location:

      Observational

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to compare functional improvement and caregiver burden pre- and post-liver transplant (LT) in four patient and patient’s primary caregiver dyads, grouped, based on presence or absence of mood symptoms pre-LT.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Jacksonville, Fla.

    Contact us for the latest status

    		View complete study & contact information
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    • Site IRB:

      • Jacksonville, Florida: 19-009275

    • Sponsor Protocol Number:

      19-009275
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