A Study to Compare Medical and Non-Medical Coping on Functional Outcomes and Caregiver Burden Among Liver Transplant Patients


About this study

The purpose of this study is to compare functional improvement and caregiver burden pre- and post-liver transplant (LT) in four patient and patient’s primary caregiver dyads, grouped, based on presence or absence of mood symptoms pre-LT.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Provision of signed and dated informed consent form.
  • Stated willingness to comply with all study procedures and availability for the duration of the study.
  • Male or female subjects, aged ≥ 18 years old.
  • Must be able to communicate in English:
    • Help of an interpreter, who can be either MCF interpreter or a family member deemed reasonably proficient and reliable by the LT team.
  • Must possess a valid and active email address to receive study questionnaire.
  • Access to digital device/s (smartphone, tablet, laptop, desktop) capable of connecting with the internet to allow study participants to complete questionnaires.
  • LT candidate listed for LT.
  • Caregiver of the LT candidate listed for LT, also agrees to participate in the study.

Exclusion Criteria:

  • Liver transplant candidates removed from the LT list.
  • Those LT candidates whose primary caregiver will not agree to participate in study.
  • Those LT candidates whose caregivers will change after LT (i.e., daughter agrees to care for the patient pre-LT; however, after LT spouse or some other family member assumes caregiving responsibility):
    • In this case, we will use baseline data to assess impact of dyadic coping on LT related outcomes until peri-LT period but will not use the data to assess the primary outcome;
    • These patients will not count toward desired sample size, as sample size calculation is based on post-LT outcomes.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Shehzad Niazi, M.D.

Open for enrollment

Contact information:

Dominique Johnson B.S.



More information


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