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Healthy Volunteer

What is this?
A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

Study phase

What is this?
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-9 of 9 for Living-donor transplant

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  1. Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants

    Rochester, MN, Jacksonville, FL, Scottsdale/Phoenix, AZ

    Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants

    • Location:

      Interventional What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    • Study phase:

      III What is this?
      During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

    About this study

    The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-101 for induction of functional immune tolerance in recipients of human leukocyte antigen (HLA)-matched, living donor kidney transplants.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

    		View complete study & contact information

    Jacksonville, Fla.

    Contact us for the latest status

    Scottsdale/Phoenix, Ariz.

    Contact us for the latest status
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 18-000785
      • Jacksonville, Florida: 18-000785
      • Scottsdale/Phoenix, Arizona: 18-000785

    • NCT ID:

      NCT03363945

    • Sponsor Protocol Number:

      MDR-101-MLK

  2. Barriers to Pre-emptive Renal Transplantation

    Rochester, MN

    Barriers to Pre-emptive Renal Transplantation

    • Location:

      Observational What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The specific purpose of this study is to compare the characteristics of patients at Mayo Clinic Rochester who received a living donor kidney transplant here preemptively versus those who dialyzed either less than 1 year or more than 1 year. 

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Closed for enrollment

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 14-005886

    • Sponsor Protocol Number:

      14-005886

  3. A Study of the Long-Term Outcomes for the Living Donors of Kidneys, based on the Anatomy A Study of the Long-Term Outcomes for the Living Donors of Kidneys, Based on the Anatomy of the Aging Remaining Kidney The Aging Kidney Anatomy Study –

    Scottsdale/Phoenix, AZ, Rochester, MN

    A Study of the Long-Term Outcomes for the Living Donors of Kidneys, based on the Anatomy A Study of the Long-Term Outcomes for the Living Donors of Kidneys, Based on the Anatomy of the Aging Remaining Kidney The Aging Kidney Anatomy Study –

    • Location:

      Observational What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to find out if the size of a donor's remaining kidney or the microscopic appearance of a tissue biopsy from the donated kidney is predictive of long-term kidney function and overall health.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

    		View complete study & contact information

    Scottsdale/Phoenix, Ariz.

    Closed for enrollment
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 15-007474
      • Scottsdale/Phoenix, Arizona: 15-007474

    • Sponsor Protocol Number:

      15-007474

  4. Collection of Blood and Urine in Healthy Patients Who are Being Considered for the Kidney Donor Program

    Scottsdale/Phoenix, AZ

    Collection of Blood and Urine in Healthy Patients Who are Being Considered for the Kidney Donor Program

    • Location:

      Observational What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to create a group of blood and urine samples from Mayo Clinic patients being screened for the kidney donor program as well as to collect risk factor data through a questionnaire. The data, blood and urine samples will be used for future research of kidney diseases at Mayo Clinic and future research at Mayo Clinic to learn about, prevent, or treat other health problems.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Scottsdale/Phoenix, Ariz.

    Open for enrollment

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Scottsdale/Phoenix, Arizona: 13-005518

    • Sponsor Protocol Number:

      13-005518

  5. A Study to Compare Urinary Exosomes in Healthy Kidney Donors and Renal Transplant Recipients

    Rochester, MN

    A Study to Compare Urinary Exosomes in Healthy Kidney Donors and Renal Transplant Recipients

    • Location:

      Observational What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to use urinary exosomes to non-invasively identify (protein biomarkers) various conditions affecting the renal transplant. 

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Contact us for the latest status

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 16-008733

    • Sponsor Protocol Number:

      16-008733

  6. Prospective Study of Gadolinium Cholangiogram in the Evaluation of Biliary Anatomy

    Rochester, MN

    Prospective Study of Gadolinium Cholangiogram in the Evaluation of Biliary Anatomy

    • Location:

      Interventional What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of the study is to determine if gadolinium cholangiogram provides adequate biliary anatomy information required for surgical decision-making prior to living-related donor right lobe liver transplantation.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 18-004032

    • Sponsor Protocol Number:

      18-004032

  7. A Transplant Program to Increase Live Donations in Hispanics

    Scottsdale/Phoenix, AZ

    A Transplant Program to Increase Live Donations in Hispanics

    • Location:

      Interventional What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to obtain valuable knowledge to rapidly promote the Hispanic Kidney Transplant Program (HKTP) as a novel approach for increasing living donor kidney transplants(LDKT) nationally in the Hispanic community.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Scottsdale/Phoenix, Ariz.

    Open for enrollment

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Scottsdale/Phoenix, Arizona: 18-006469

    • NCT ID:

      NCT03276390

    • Sponsor Protocol Number:

      NCT03276390

  8. Evaluation of the Live Donor Assessment Tool (LDAT) to Predict Psychosocial Outcomes among Liver and Kidney Donors

    Rochester, MN

    Evaluation of the Live Donor Assessment Tool (LDAT) to Predict Psychosocial Outcomes among Liver and Kidney Donors

    • Location:

      Observational What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to determine if the Living Donor Assessment Tool (LDAT) is an effective tool to improve the psychosocial evaluation of potential live kidney and liver donors. The LDAT was developed by the living donation team at the Zweig Family Center for Living Donation at the Mount Sinai Recanati/Miller Transplantation Institute. It assesses important areas of the evaluation process such as motivation (reason) for donation, knowledge of living donation, support, relationship to organ recipient, feelings about donation, stability in life and psychiatric and addiction history and provides a score that can be used to measure the risks and/or the appropriateness of a live organ donor candidate.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Closed for enrollment

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 15-003696

    • Sponsor Protocol Number:

      15-003696

  9. A Study to Learn More About the Chemicals Produced by Cells Involved in Liver Regeneration (regrowth) After Living Liver Donation

    Rochester, MN

    A Study to Learn More About the Chemicals Produced by Cells Involved in Liver Regeneration (regrowth) After Living Liver Donation

    • Location:

      Observational What is this?

      Describes the nature of a clinical study. Types include:

      • Observational study — observes people and measures outcomes without affecting results.
      • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
      • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

    About this study

    The purpose of this study is to characterize the readily available (circulating in peripheral blood) mediators of cell proliferation in individuals undergoing living liver donation.

    Participating Mayo Clinic locations

    Study statuses change often. Please contact us for help.

    Mayo Clinic Location Status Contact

    Rochester, Minn.

    Open for enrollment

    		View complete study & contact information
    Print study details

    Study IDs

    • Site IRB:

      • Rochester, Minnesota: 17-007453

    • Sponsor Protocol Number:

      17-007453
.

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