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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 31-40 of 96 for Melanoma

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  1. Dabrafenib in Treating Patients With Solid Tumors and Kidney or Liver Dysfunction

    Rochester, MN

  2. A Study of the Combination of IMCgp100 with Durvalumab and/or Tremelimumab for Patients with Advanced Cutaneous Melanoma

    Jacksonville, FL

  3. A Phase 2/3 Study of Indoximod or Placebo Plus Pembrolizumab or Nivolumab in Subjects With Unresectable or Metastatic Melanoma

    Rochester, MN

  4. Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma

    Jacksonville, FL

  5. High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  6. Study of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma Patients

    Rochester, MN

  7. Study of TBio-6517, Given Intratumorally, Alone or in Combination With Pembrolizumab, in Solid Tumors

    Scottsdale/Phoenix, AZ, Rochester, MN, Jacksonville, FL

  8. Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients with Stage IV Melanoma, Gynecologic Cancers, and Other Malignancies that Cannot be Removed by Surgery

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  9. Phase 1b Safety Study of CMB305 in Patients With Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1

    Rochester, MN

  10. A Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Unilateral Head and Neck Cancer

    Rochester, MN

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