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(for at least one location)
Rochester, MN, Jacksonville, FL
Describes the nature of a clinical study. Types include:
The purpose of this study is to determine whether off-pump bilateral orthotopic lung transplantation (BOLT) or venoarterial extracorporeal membrane oxygenation (VA ECMO) lung transplantation results in higher PGD grade 3 at 48-72 hours, mortality at 90 days, and the combination of these two endpoints.
Secondly, to determine whether off-pump or VA ECMO lung transplantation has more red blood cell transfusion (intraoperative plus the first 24 hours in the ICU), chest tube output the first 24 hours, incidence of re-exploration for bleeding, air emboli, stroke, PGD grade 3 at T0 and T24, pneumonia, need for dialysis, rejection, bronchial dehiscence, tracheostomy, length of mechanical ventilation, and hospital length of stay.
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Open for enrollment
Closed for enrollment
Jacksonville, FL
A normal lung ultrasound artifact pattern in an aymptomatic lung transplant recipient with normal chest radiograph and spirometry can safely exclude significant acute cellular rejection.
The purpose of this study is to examine the effectiveness of a phone call ≤ 30 minute per session, 12-session, weekly individual health-coaching intervention, completed over 12-16 weeks in adults on the lung transplant waiting list versus usual transplant care.
The purpose of this study is to to mechanistically investigate the effect of specific inspiratory muscle training on respiratory function, exercise capacity, health-related quality-of-life, and short-term clinical outcomes in patients after lung transplant.
The purpose of this study is to evaluate patient acceptance to participate, retention, feasibility of randomization, and acceptability and compliance with a novel 12-week, home-based, multimodal prehabilitation program in waitlisted lung transplant candidates.
Rochester, MN
This study is being done to develop a serum and tissue bank for future research of patients with heart failure, mechanical circulatory support and/or cardiothoracic transplants. This blood/tissue will be used for three principle purposes: (1) laboratory tests which will be available in the future but that are not currently available and which may be of benefit to the patient, (2) review of previous patient laboratory results made necessary by development of a new disease process by the patient, and (3) future unspecified research purposes.
The purpose of this study is to explore adherence, barriers, side effects, and preference for pharmacologic antifungal prophylaxis following lung transplant.
The purpose of this study is to to determine if Cardiopulmonary Bypass (CPB) is an independent risk factor for development of Primary Graft Dysfunction (PGD) as compared to Extracorporeal Membrane Oxygenation (ECMO) even when adjusted for all other recipient, donor, biologic and operative risk factors.
The aim of this study is to evaluate a novel NGS-based assay for early detection of increased amounts of dd-cfDNA and its correlation to acute graft rejection and development of chronic lung allograft dysfunction (CLAD), and to improve the rejection diagnostics of patients after transplantation in order to empower early clinical intervention and thereby prolong the potential survival of the graft.
The purpose of this study is to develop non-invasive diagnostics for lower respiratory tract colonization and invasion by Pseudomonas aeruginosa (PA), one of the most serious infections in hospitals.