Clinical Trials

A Trial of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

Rochester, MN, Jacksonville, FL

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A Trial of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to determine whether off-pump bilateral orthotopic lung transplantation (BOLT) or venoarterial extracorporeal membrane oxygenation (VA ECMO) lung transplantation results in higher PGD grade 3 at 48-72 hours, mortality at 90 days, and the combination of these two endpoints.

Secondly, to determine whether off-pump or VA ECMO lung transplantation has more red blood cell transfusion (intraoperative plus the first 24 hours in the ICU), chest tube output the first 24 hours, incidence of re-exploration for bleeding, air emboli, stroke, PGD grade 3 at T0 and T24, pneumonia, need for dialysis, rejection, bronchial dehiscence, tracheostomy, length of mechanical ventilation, and hospital length of stay.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment	View complete study & contact information

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Site IRB:
22-005691
NCT ID:
NCT05547698
Sponsor Protocol Number:
VIP BOLT

A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

Jacksonville, FL

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A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

A normal lung ultrasound artifact pattern in an aymptomatic lung transplant recipient with normal chest radiograph and spirometry can safely exclude significant acute cellular rejection.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
20-002489
NCT ID:
NCT04582279

Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

Rochester, MN, Jacksonville, FL

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Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to examine the effectiveness of a phone call ≤ 30 minute per session, 12-session, weekly individual health-coaching intervention, completed over 12-16 weeks in adults on the lung transplant waiting list versus usual transplant care.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
21-002675
NCT ID:
NCT05426200

A Study to Evaluate the Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes Following Lung Transplant

Jacksonville, FL

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A Study to Evaluate the Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes Following Lung Transplant

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to to mechanistically investigate the effect of specific inspiratory muscle training on respiratory function, exercise capacity, health-related quality-of-life, and short-term clinical outcomes in patients after lung transplant.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
20-012778
NCT ID:
NCT04783155

Novel Remote Monitoring-enabled Home-Based Prehabilitation for Lung Transplant Candidates

Jacksonville, FL

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Novel Remote Monitoring-enabled Home-Based Prehabilitation for Lung Transplant Candidates

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to evaluate patient acceptance to participate, retention, feasibility of randomization, and acceptability and compliance with a novel 12-week, home-based, multimodal prehabilitation program in waitlisted lung transplant candidates.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
24-013245

A Study To Test How Effective Belumosudil Tablets Are For Treating Adult Participants With Chronic Lung Allograft Dysfunction (ROCKaspire)

Jacksonville, FL, Rochester, MN

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A Study To Test How Effective Belumosudil Tablets Are For Treating Adult Participants With Chronic Lung Allograft Dysfunction (ROCKaspire)

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The objective of this study is to investigate the efficacy and safety of belumosudil compared with placebo, both administered on top of azithromycin and standard-of-care regimen of immunosuppression in male or female participants at least 1 year after bilateral lung transplant, who are at least 18 years of age and who have evidence of progressive CLAD despite azithromycin therapy.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information
Rochester, MN	Contact us for the latest status	View complete study & contact information

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Site IRB:
23-009793
NCT ID:
NCT06082037
Sponsor Protocol Number:
SAR445761-EFC17801

Heart Failure and Cardiothoracic Transplant Biorepository

Rochester, MN

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Heart Failure and Cardiothoracic Transplant Biorepository

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

This study is being done to develop a serum and tissue bank for future research of patients with heart failure, mechanical circulatory support and/or cardiothoracic transplants. This blood/tissue will be used for three principle purposes: (1) laboratory tests which will be available in the future but that are not currently available and which may be of benefit to the patient, (2) review of previous patient laboratory results made necessary by development of a new disease process by the patient, and (3) future unspecified research purposes.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information

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Site IRB:
162-95
Sponsor Protocol Number:
162-95

Trifecta-Lung CfDNA-MMDx Study

Jacksonville, FL

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Trifecta-Lung CfDNA-MMDx Study

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to demonstrate the relationship between dd-cfDNA levels and HLA antibodies in blood transplant recipient and Demonstrate the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from lung transplants.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

Print study details

Site IRB:
24-010456
NCT ID:
NCT05837663
Sponsor Protocol Number:
Trifecta-Lung

A Study to Analyze Lung Transplant Recipients’ Perspective on Antifungal Prophylaxis

Rochester, MN, Jacksonville, FL

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A Study to Analyze Lung Transplant Recipients’ Perspective on Antifungal Prophylaxis

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to explore adherence, barriers, side effects, and preference for pharmacologic antifungal prophylaxis following lung transplant.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
19-006102
Sponsor Protocol Number:
19-006102

Cardio-Pulmonary Bypass Versus Extracorporeal Membrane Oxygenation as an Independent Risk Factor for Development of Primary Graft Dysfunction Post Lung Transplant

Jacksonville, FL

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Cardio-Pulmonary Bypass Versus Extracorporeal Membrane Oxygenation as an Independent Risk Factor for Development of Primary Graft Dysfunction Post Lung Transplant

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to to determine if Cardiopulmonary Bypass (CPB) is an independent risk factor for development of Primary Graft Dysfunction (PGD) as compared to Extracorporeal Membrane Oxygenation (ECMO) even when adjusted for all other recipient, donor, biologic and operative risk factors.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

Print study details

Site IRB:
20-006346

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Search Results 1-10 of 16 for

A Trial of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

A Study to Evaluate the Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes Following Lung Transplant

Novel Remote Monitoring-enabled Home-Based Prehabilitation for Lung Transplant Candidates

A Study To Test How Effective Belumosudil Tablets Are For Treating Adult Participants With Chronic Lung Allograft Dysfunction (ROCKaspire)

Heart Failure and Cardiothoracic Transplant Biorepository

Trifecta-Lung CfDNA-MMDx Study

A Study to Analyze Lung Transplant Recipients’ Perspective on Antifungal Prophylaxis

Cardio-Pulmonary Bypass Versus Extracorporeal Membrane Oxygenation as an Independent Risk Factor for Development of Primary Graft Dysfunction Post Lung Transplant

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