A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients


About this study

A normal lung ultrasound artifact pattern in an aymptomatic lung transplant recipient with normal chest radiograph and spirometry can safely exclude significant acute cellular rejection.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult patients (> 18 yrs) who had undergone single/double/heart-lung transplant
  • Asymptomatic
  • Normal spirometry defined as a FEV1 without signifcant drop from baseline (significant drop = >10% decrease from baseline)
  • Clear chest radiograph over allograft

Exclusion Criteria:

  • Patients who are unable to consent for the procedure
  • Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquision- as deemed by the operator.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Tathagat Narula, M.B.B.S., M.D.

Open for enrollment

Contact information:

Katelyn Register M.S., C.C.R.C.

(904) 953-8503


More information


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