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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 2831-2840 of 10669

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  1. Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia

  2. Outcomes of Advanced Practice Providers Focused Cardiac Ultrasound Training

    Scottsdale/Phoenix, AZ

  3. The International Diabetes Closed Loop (iDCL) Trial: Protocol 1

    Rochester, MN

  4. TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

    Scottsdale/Phoenix, AZ, Rochester, MN

  5. Efficacy and Safety of Maribavir in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment

    Rochester, MN

  6. Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival

    Rochester, MN, Jacksonville, FL

  7. Diet, Vascular Health and the Gut Microbiome in Heart Failure

    Scottsdale/Phoenix, AZ

  8. An Investigational Immuno-therapy Study of Nivolumab Combined With Ipilimumab Compared to Nivolumab by Itself After Complete Surgical Removal of Stage IIIb/c/d or Stage IV Melanoma

    Rochester, MN

  9. A 4-Week Study of the Safety, Efficacy, and Pharmacokinetics of JZP-110 [(R)-2-amino-3-phenylpropylcarbamate Hydrochloride] in Subjects With Parkinson's Disease and Excessive Sleepiness

    Scottsdale/Phoenix, AZ

  10. International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

    Rochester, MN

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