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The VITAL Amyloidosis Study, A Global Phase 3, Efficacy And Safety Study Of NEOD001 In Patients With AL Amyloidosis

Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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The VITAL Amyloidosis Study, A Global Phase 3, Efficacy And Safety Study Of NEOD001 In Patients With AL Amyloidosis

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This is a multi-center, international, randomized, double-blind, placebo-controlled, two-arm efficacy and safety study in subjects newly diagnosed with AL amyloidosis. Subjects will remain on-study until study completion, which will occur when all primary endpoint events (all-cause mortality or cardiac hospitalizations) have been reached.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment
Rochester, MN	Closed for enrollment

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Site IRB:
15-000659
NCT ID:
NCT02312206
Sponsor Protocol Number:
NEOD001-CL002

A Study Of BBI608 Combined With Standard Chemotherapies In Adult Patients Who Have Pancreatic Cancer

Scottsdale/Phoenix, AZ
- See Details
A Study Of BBI608 Combined With Standard Chemotherapies In Adult Patients Who Have Pancreatic Cancer
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  1
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The purpose of this study is to assess the safety, tolerability, and best study dose of BBI608 when administered in combination with Gemcitabine and nab-Paclitaxel, mFOLFIRINOX, FOLFIRI, or with MM-398, 5-FU and leucovorin in patients who have pancreatic adenocarcinoma that has spread.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, AZ

Closed for enrollment
View complete study & contact information

Print study details
Site IRB:
16-004349

NCT ID:
NCT02231723

Sponsor Protocol Number:
BBI608-118
A Study Of The Long-Term Safety Of Tafamidis In Subjects With Transthyretin Cardiomyopathy

Scottsdale/Phoenix, AZ
- See Details
A Study Of The Long-Term Safety Of Tafamidis In Subjects With Transthyretin Cardiomyopathy
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  3
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The purpose of this study is to evaluate the safety of oral daily dosing of tafamidis meglumine for patients who have either transthyretin genetic variations or wild-type transthyretin, resulting in amyloid disease of the heart muscle.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, AZ

Closed for enrollment
View complete study & contact information

Print study details
Site IRB:
16-005885

NCT ID:
NCT02791230

Sponsor Protocol Number:
B3461045

Study Of The Combination Of AFM13 And Pembrolizumab In Patients With Relapsed Or Refractory Classical Hodgkin Lymphoma

Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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Study Of The Combination Of AFM13 And Pembrolizumab In Patients With Relapsed Or Refractory Classical Hodgkin Lymphoma

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
1
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to establish a dosing regimen for the combination therapy of AFM13 and pembrolizumab (MK-3475) in patients with relapsed or refractory (R/R) Hodgkin Lymphoma (HL) and to assess the safety and tolerability of this combination therapy.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment
Rochester, MN	Closed for enrollment

Print study details

Site IRB:
16-000563
NCT ID:
NCT02665650
Sponsor Protocol Number:
AFM13-103

A Study To Evaluate ION251 To Treat Patients With Relapsed/Refractory Multiple Myleoma

Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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A Study To Evaluate ION251 To Treat Patients With Relapsed/Refractory Multiple Myleoma

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
1
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to determine the maximum-tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of ION251 in patients with relapsed/refractory multiple myeloma.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Closed for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment
Rochester, MN	Closed for enrollment

Print study details

Site IRB:
20-010126
NCT ID:
NCT04398485
Sponsor Protocol Number:
ION251-CS1

A Study To Compare The Effectiveness, Safety And Tolerability Of P1101 Vs. Anagrelide For Essential Thrombocythemia

Scottsdale/Phoenix, AZ
- See Details
A Study To Compare The Effectiveness, Safety And Tolerability Of P1101 Vs. Anagrelide For Essential Thrombocythemia
- Study type:
  Interventional
  Describes the nature of a clinical study. Types include:
  
  Observational study — observes people and measures outcomes without affecting results.
  
  Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
  
  Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Study phase:
  3
  During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study

The primary purpose of this study is to assess long-term safety and effectiveness of P1101 in terms of response rate for Essential Thrombocythemia

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, AZ

Closed for enrollment
View complete study & contact information

Print study details
Site IRB:
20-008989

NCT ID:
NCT04285086

Sponsor Protocol Number:
P1101 ET

Pagination Clinical studies

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Search Results 1431-1440 of 2503

The VITAL Amyloidosis Study, A Global Phase 3, Efficacy And Safety Study Of NEOD001 In Patients With AL Amyloidosis

A Study Of BBI608 Combined With Standard Chemotherapies In Adult Patients Who Have Pancreatic Cancer

A Study Of The Long-Term Safety Of Tafamidis In Subjects With Transthyretin Cardiomyopathy

Study Of The Combination Of AFM13 And Pembrolizumab In Patients With Relapsed Or Refractory Classical Hodgkin Lymphoma

Study Of Pembrolizumab (MK-3475) Vs Standard Therapy In Participants With Microsatellite Instability-High (MSI-H) Or Mismatch Repair Deficient (DMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177)

Study To Determine Safety And Effectiveness Of Ascorbic Acid, Corticosteroids, And Thiamine In Treating Sepsis And Septic Shock

Study Investigating The Activity Of Vidofludimus Calcium As A Treatment For Primary Sclerosing Cholangitis (PSC)

A Study Of Momelotinib Versus Danazol In Symptomatic And Anemic Myelofibrosis Patients

A Study To Evaluate ION251 To Treat Patients With Relapsed/Refractory Multiple Myleoma

A Study To Compare The Effectiveness, Safety And Tolerability Of P1101 Vs. Anagrelide For Essential Thrombocythemia

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