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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 144 for nephrology OR kidney

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  1. Dosing Regimen of Eculizumab Added to Conventional Treatment in Positive Crossmatch Deceased Donor Kidney Transplant

    Rochester, MN

  2. A Study of the Benefits and Risks of Nulojix® (Belatacept)-Based Maintenance Immune Rejection Suppression for Kidney Transplant Recipients

    Scottsdale/Phoenix, AZ

  3. A Study to Examine The Effectiveness, Feasibility, and Acceptability of Exercise Intervention on Frailty After Kidney Transplantation.

    Rochester, MN

  4. Senescence in Chronic Kidney Disease

    Rochester, MN

  5. Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients (IMAGINE)

    Scottsdale/Phoenix, AZ, Rochester, MN

  6. A Study to Evaluate Bardoxolone Methyl in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

    Rochester, MN

  7. A Study to Assess if Contrast-Enhanced Ultrasound Positively Influences the Selection of Biopsy Sites When Evaluating Transplant Kidneys

    Scottsdale/Phoenix, AZ

  8. A Study of the Long-Term Safety, Tolerability, and Effectiveness of Tesevatinib for Patients Completing 24 Months of Treatment for Autosomal Dominant Polycystic Kidney Disease

    Rochester, MN

  9. A Study to Evaluate Home-Based Exercise as an Intervention for Treating Patients with Varying Levels of Kidney Function

    Rochester, MN

  10. Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Dialysis (ASCEND-D)

    Jacksonville, FL

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