A Study of Markers in the Blood and/or Stored Kidney Biopsy Tissue in Patients with a History of Childhood Onset of Membranous Nephropathy


About this study

The study is being done to look for markers in the blood and/or stored kidney biopsy tissue, in patients with a history of childhood onset Membranous Nephropathy. By collecting health information and laboratory samples, our goal is to learn more about membranous nephropathy.

Due to discovery of additional antibodies and antigens (Thrombospondin Type-1 Domain 7A, Semaphorin 3B, Exotosin-1 & 2, Neural epidermal growth factor-like type 1, Protocadherin 7 PCDH7, Protocadherin FAT1, and serine protease HTRA1) in children with MN over the last decade, we would like to expand serological and hisotological testing of these antibodies and antigens in the existing and archived samples to ensure a comprehensive investigation of this disease in the current study.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age <17 years old at diagnosis of MN (this is diagnosis age only)
  • Present age less than 21 years old
  • Biopsy proven Membranous Nephropathy in all patients.
  • Secondary Membranous Nephropathy (non-infectious etiology) will be used as controls.

Exclusion Criteria: 

  • Secondary MN due to infectious causes.
  • Inability or unwillingness of individual or legal guardian/representative to give written informed consent.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Cheryl Tran, M.D.

Closed for enrollment

Contact information:

Cheryl Tran M.D.


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