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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 71 for joint replacement

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  1. A Study to Evaluate Safety and Effectiveness of Bacteriophage Treatment in Patients with Prosthetic Joint Infections

    Rochester, MN

  2. Tranexamic Acid in Revision Total Joint Arthroplasty

    Rochester, MN

  3. A Study of Static versus Articulating Antibiotic Spacer for Periprosthetic Joint Infection in Total Knee Arthroplasty

    Rochester, MN

  4. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Rochester, MN

  5. Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement

    Scottsdale/Phoenix, AZ

  6. A Study to Compare Pain Protocol With and Without Opioids Following Total Joint Arthroplasty

    Jacksonville, FL

  7. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Scottsdale/Phoenix, AZ

  8. Using Ice Around Postoperative Total Knee Incisions – Does This Make Sense?

    Jacksonville, FL

  9. A Study to Compare the Outcome of Primary Anatomic Shoulder Arthroplasty Using the Stryker ReUnion System with Implantation of Either a Peg or Keel Glenoid Construction.

    Rochester, MN

  10. Mobile Educations Effect on Pain Outcomes

    Rochester, MN

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