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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 261-270 of 304 for heart disease

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  1. A Study of the Impact of Frailty on Health Outcomes following Aortic Valve Replacement

    Rochester, MN

  2. A Study of Software Aided Angle Measurements to Improve Total Aortic Valve Replacement

    Rochester, MN

  3. A Study of Aortic Valve Gradient Severity in Patients with Atrial Fibrillation

    Rochester, MN

  4. Determining Patient and Provider Values and Preferences for Initial Atrial Fibrillation Education

    Rochester, MN

  5. Outcomes of Percutaneous Revascularization for Management of Surgically Ineligible Patients With Multivessel or Left Main Coronary Artery Disease: A Prospective Registry

    Rochester, MN

  6. Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair

    Rochester, MN

  7. Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes

    Scottsdale/Phoenix, AZ

  8. Cardiotoxic Effects of Chemotherapy in Patients with Sarcomas

    Rochester, MN

  9. Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies

    Jacksonville, FL

  10. A Study to Identify Late-Occurring Complications in Childhood Cancer Survivors

    Rochester, MN

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