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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 78 for cardiology

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  1. A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

    Jacksonville, FL

  2. CardiAMP™ Heart Failure Trial

    Scottsdale/Phoenix, AZ

  3. A Study to Evaluate the use of Real Time Myocardial Perfusion Echocardiography for Detection of Coronary Allograft Vasculopathy in Heart Transplant Patients

    Rochester, MN

  4. A Study of the Best Position for the Passive Driver (Vibration Transmitter) in Cardiac Magnetic Resonance Elastography (MRE)

    Rochester, MN

  5. Study to Assess Cardiac Dyspnea Using Exercise Cardiac Magnetic Resonance as a Diagnostic Tool

    Jacksonville, FL

  6. d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis

    Rochester, MN

  7. A Study to Assess Myocardial Blood Flow Changes in Oncology Patients

    Rochester, MN

  8. NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery

    Rochester, MN

  9. A Study to See if Clinical Cardiac MRI Scanning Can Cause DNA Damage

    Rochester, MN

  10. Phase I Safety and Feasibility Study of Intracoronary Delivery of Autologous Bone Marrow Derived Mononuclear Cells

    Rochester, MN

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