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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 79 for cardiology

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  1. A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

    Jacksonville, FL

  2. A Study to Evaluate the use of Real Time Myocardial Perfusion Echocardiography for Detection of Coronary Allograft Vasculopathy in Heart Transplant Patients

    Rochester, MN

  3. A Study to Evaluate Autologous Bone Marrow Mononuclear Cells Using the CardiAMP™ Cell Therapy in Patients With Post Myocardial Infarction Heart Failure

    Scottsdale/Phoenix, AZ

  4. A Study to Evaluate the Safety and Effectiveness of GORE® CARDIOFORM Septal Occluder to Treat Migraine Headaches

    Scottsdale/Phoenix, AZ

  5. d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis

    Rochester, MN

  6. A Study to Assess Myocardial Blood Flow Changes in Oncology Patients

    Rochester, MN

  7. A Study of the Best Position for the Passive Driver (Vibration Transmitter) in Cardiac Magnetic Resonance Elastography (MRE)

    Rochester, MN

  8. A Study to Evaluate the Safety and Tolerability of LCZ696 Followed by a 52-week Study of LCZ696 Compared With Enalapril in Pediatric Patients with Heart Failure

    Rochester, MN

  9. A Study to Compare Conventional Heart Echo Measurements with Newer 2 and 3 Dimensional Measurements of Mechanical Heart Strain after Trastuzumab Infusion

    Rochester, MN

  10. NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery

    Rochester, MN

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