A Study to Evaluate the use of Real Time Myocardial Perfusion Echocardiography for Detection of Coronary Allograft Vasculopathy in Heart Transplant Patients


About this study

The purpose of this study is to see if the use of real time ultrasound of heart muscle perfusion is a usable and effective non-invasive way to detect Coronary Allograft Vasculopathy (heart transplant caused blood vessel disease) in child and adult heart transplant patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria

  • Cardiac transplant recipients (>10 months post transplant)
  • Clinically followed at Mayo Clinic (Rochester Mn)

Exclusion Criteria

  • Standard contraindications to the use of ultrasound contrast and pharmacologic stress
  • Recent (<3 months) hospitalization for heart failure, acute coronary syndrome or allograft rejection
  • Multi-organ transplant
  • Known or suspected right-to-left, bi-directional or transient right-to-left cardiac shunts
  • Hypersensitivity to perflutren

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jonathan Johnson, M.D.

Closed for enrollment

Contact information:

Shalon Maxson R.N.



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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