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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 12 for Primary lateral sclerosis

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  1. Diaphragm Pacing System (DPS) in Participants with Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL

  2. A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 in Amyotrophic Lateral Sclerosis (ALS) Patients

    Jacksonville, FL

  3. A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis

    Jacksonville, FL

  4. A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral Sclerosis

    Jacksonville, FL

  5. A Study to Evaluate the Effectiveness, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB067 Administered to Adult Subjects with Amyotrophic Lateral Sclerosis and Confirmed Superoxide Dismutase 1 Mutation

    Jacksonville, FL, Rochester, MN

  6. Development of a PLS-Specific Clinical Rating Scale, Capable of Evaluating the Clinical Functional State of Patients with PLS in Multi-Site Study

    Jacksonville, FL, Rochester, MN

  7. A Study to Evaluate the Long-Term Effectives on ALS Disease Progression of BIIB067

    Jacksonville, FL, Rochester, MN

  8. Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS

    Jacksonville, FL

  9. A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.

    Jacksonville, FL

  10. A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps

    Scottsdale/Phoenix, AZ

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