Clinical Trials

A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

Jacksonville, FL

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A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

A normal lung ultrasound artifact pattern in an aymptomatic lung transplant recipient with normal chest radiograph and spirometry can safely exclude significant acute cellular rejection.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
20-002489
NCT ID:
NCT04582279

A Trial of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

Rochester, MN, Jacksonville, FL

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A Trial of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to determine whether off-pump bilateral orthotopic lung transplantation (BOLT) or venoarterial extracorporeal membrane oxygenation (VA ECMO) lung transplantation results in higher PGD grade 3 at 48-72 hours, mortality at 90 days, and the combination of these two endpoints.

Secondly, to determine whether off-pump or VA ECMO lung transplantation has more red blood cell transfusion (intraoperative plus the first 24 hours in the ICU), chest tube output the first 24 hours, incidence of re-exploration for bleeding, air emboli, stroke, PGD grade 3 at T0 and T24, pneumonia, need for dialysis, rejection, bronchial dehiscence, tracheostomy, length of mechanical ventilation, and hospital length of stay.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment	View complete study & contact information

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Site IRB:
22-005691
NCT ID:
NCT05547698
Sponsor Protocol Number:
VIP BOLT

Novel Remote Monitoring-enabled Home-Based Prehabilitation for Lung Transplant Candidates

Jacksonville, FL

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Novel Remote Monitoring-enabled Home-Based Prehabilitation for Lung Transplant Candidates

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to evaluate patient acceptance to participate, retention, feasibility of randomization, and acceptability and compliance with a novel 12-week, home-based, multimodal prehabilitation program in waitlisted lung transplant candidates.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
24-013245

A Study to Evaluate the Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes Following Lung Transplant

Jacksonville, FL

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A Study to Evaluate the Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes Following Lung Transplant

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to to mechanistically investigate the effect of specific inspiratory muscle training on respiratory function, exercise capacity, health-related quality-of-life, and short-term clinical outcomes in patients after lung transplant.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
20-012778
NCT ID:
NCT04783155

Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

Rochester, MN, Jacksonville, FL

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Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to examine the effectiveness of a phone call ≤ 30 minute per session, 12-session, weekly individual health-coaching intervention, completed over 12-16 weeks in adults on the lung transplant waiting list versus usual transplant care.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
21-002675
NCT ID:
NCT05426200

Cryoprobe Biopsy in Chronic Rejection in Lung Transplant Recipients

Rochester, MN

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Cryoprobe Biopsy in Chronic Rejection in Lung Transplant Recipients

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to to compare the histological quality and diagnostic yield of tissue samples acquired using a 1.1 mm cryoprobe with those obtained through forceps biopsies in lung transplant recipients for graft surveillance.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information

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Site IRB:
23-011339

12-week Program of Modified Latin Dance for Post- Lung Transplant Patients

Jacksonville, FL

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12-week Program of Modified Latin Dance for Post- Lung Transplant Patients

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to establish if a 12-week program of modified Latin dance can improve balance, reduce kinesiophobia, improve depression, anxiety scales and home spirometry in postlung transplant patients.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
23-001508
NCT ID:
NCT05924113

Lung Transplant Candidates Transseptal ECMO with the Protek Solo Cannula with Right Heart Failure from Pulmonary Hypertension

Jacksonville, FL

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Lung Transplant Candidates Transseptal ECMO with the Protek Solo Cannula with Right Heart Failure from Pulmonary Hypertension

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to determine if transseptal ECMO can bridge PH-RVF patients to lung transplant safely.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, FL	Open for enrollment	View complete study & contact information

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Site IRB:
24-000660
NCT ID:
NCT06770023

Study To Evaluate ARINA-1 In The Prevention Of Bronchiolitis Obliterans Progression In Participants With Bilateral Lung Transplant

Rochester, MN

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Study To Evaluate ARINA-1 In The Prevention Of Bronchiolitis Obliterans Progression In Participants With Bilateral Lung Transplant

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The goal of this Phase 3 clinical trial is to compare ARINA-1 (a nebulized immunomodulatory agent) plus Standard of Care vs Standard of Care alone. The main question it aims to answer are:

* Evaluate the effectiveness of ARINA-1 in preventing bronchiolitis obliterans syndrome (BOS) progression in participants with a bilateral lung transplant
* To evaluate the effectiveness of ARINA-1 on improving quality of life decline and preventing or delaying the use of augmented immunosuppression in participants with pre-BOS relative to SOC.

Participants will have clinic visits at screening, randomization (day 1) and weeks 4, 12, 18, and 24. After week 24, participants will have clinic visits at weeks 32, 40, and 48.

Participants will also have a telehealth visit on day 2 and phone calls to assess adverse events (AEs), serious adverse events (SAEs), and review patient education will occur during weeks 5, 8, 36, and 44.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Contact us for the latest status	View complete study & contact information

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Site IRB:
26-003226
NCT ID:
NCT05654922

A Study to Analyze Lung Transplant Recipients’ Perspective on Antifungal Prophylaxis

Rochester, MN, Jacksonville, FL

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A Study to Analyze Lung Transplant Recipients’ Perspective on Antifungal Prophylaxis

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to explore adherence, barriers, side effects, and preference for pharmacologic antifungal prophylaxis following lung transplant.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information
Jacksonville, FL	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
19-006102
Sponsor Protocol Number:
19-006102

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Search Results 1-10 of 19 for Lung transplant

A Study to Verify the Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

A Trial of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

Novel Remote Monitoring-enabled Home-Based Prehabilitation for Lung Transplant Candidates

A Study to Evaluate the Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes Following Lung Transplant

Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

Cryoprobe Biopsy in Chronic Rejection in Lung Transplant Recipients

12-week Program of Modified Latin Dance for Post- Lung Transplant Patients

Lung Transplant Candidates Transseptal ECMO with the Protek Solo Cannula with Right Heart Failure from Pulmonary Hypertension

Study To Evaluate ARINA-1 In The Prevention Of Bronchiolitis Obliterans Progression In Participants With Bilateral Lung Transplant

A Study to Analyze Lung Transplant Recipients’ Perspective on Antifungal Prophylaxis

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