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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 26 for Alzheimer's disease

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  • Study status: Open/Status Unknown
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  1. A Long Term Study of Molecular and Structural Imaging in Atypical Alzheimer's Disease

    Rochester, MN

  2. A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies

    Rochester, MN, Jacksonville, FL

  3. A Study to Evaluate the Safety and Effectiveness of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

    Scottsdale/Phoenix, AZ

  4. A Study to Evaluate Compensatory Training to Support Everyday Function and Adherence to Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease

    Scottsdale/Phoenix, AZ

  5. A Study to Evaluate the Effectiveness and Safety of BAN2401 to Treat Subjects with Preclinical Alzheimer’s Disease and Elevated Amyloid (A45 Trial) and in Subjects with Early Preclinical Alzheimer’s Disease and Intermediate Amyloid

    Rochester, MN, Jacksonville, FL

  6. Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss

    Jacksonville, FL, Rochester, MN

  7. A Study Evaluating the Use of 48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer’s Disease

    Jacksonville, FL

  8. A Study to Develop A Family Registry to Collect Alzheimer's Biomarkers

    Jacksonville, FL

  9. Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol

    Jacksonville, FL, Rochester, MN

  10. Mayo Alzheimer's Disease Research Center

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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