Clinical Trials

Outcome Reflection for Immune Mediated Rejection by Utilizing AI in Cardiac Transplant During Early and Late Echocardiographic Analysis

Rochester, MN

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Outcome Reflection for Immune Mediated Rejection by Utilizing AI in Cardiac Transplant During Early and Late Echocardiographic Analysis

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
0
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to formulate a prospective cohort of Heart transplant patients (encompassing adult populations) who will be undergoing post heart transplant surveillance with endomyocardial biopsies.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 23-006378
NCT ID:
NCT06178744

A Study of a Deep Learning Method for Cardiac CINE MRI

Rochester, MN

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A Study of a Deep Learning Method for Cardiac CINE MRI

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
0
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to develop and test software that may improve MRI imaging by shortening the exam time.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 25-000864

Serum and Portal Vein Extracellular Vesicles in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

Jacksonville, FL

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Serum and Portal Vein Extracellular Vesicles in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
0
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The purpose of this study is to confirm that peripheral blood miRNA levels are sufficient to serve as FHP serum biomarkers.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla.	Open for enrollment	View complete study & contact information

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Site IRB:
- Jacksonville, Florida: 25-003836

A Study Of Intestinal Permeability And Microbiota In HE

Rochester, MN

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A Study Of Intestinal Permeability And Microbiota In HE

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to determine the importance of intestinal permeability and microbiota in hepatic encephalopathy (HE).

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Contact us for the latest status	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 25-005596

Development Of Non-invasive Cell-free DNA To Supplant Invasive Biopsy In Heart Transplantation

Jacksonville, FL

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Development Of Non-invasive Cell-free DNA To Supplant Invasive Biopsy In Heart Transplantation

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to describe the association between Prospera dd-cfDNA measures and other diagnostic tests used to detect heart allograft rejection and/or njury, including histology, echocardiography and DSA, in the first post-transplant year. Additionally, to inform rates of clinical outcomes in a contemporary cohort of adult heart transplant recipients to determine power for a future randomized, controlled clinical trial.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla.	Closed for enrollment	View complete study & contact information

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Site IRB:
- Jacksonville, Florida: 22-007194
NCT ID:
NCT05309382
Sponsor Protocol Number:
22-062-TRP

ATHNdataset Registry

Rochester, MN

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ATHNdataset Registry

About this study

The purpose of this study is to provide a secure, comprehensive registry of real-world clinical data, the ATHNdataset, to support standardized data collection at ATHN affiliated blood disorder treatment centers for persons living with blood disorders to support clinical outcomes analysis, research, advocacy, and public health reporting for the blood disorders community.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 25-005525
Sponsor Protocol Number:
ATHNdataset Registry

A Study Of Automated Manual Lymphatic Drainage Therapy For Obstructive Sleep Apnea

Rochester, MN

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A Study Of Automated Manual Lymphatic Drainage Therapy For Obstructive Sleep Apnea

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to evaluate whether enhancing systemic lymphatic drainage using an automated manual lymphatic drainage therapy (AMLDT) device⁷ can improve glymphatic clearance in patients with OSA, as measured by changes in serum biomarkers related to AD pathology (Aβ42, Aβ40, Aβ42/Aβ40 ratio, and p-tau-217), neurodegeneration/white matter integrity (neurofilament light chain), and neuroinflammation (glial fibrillary acidic protein). The AMLDT device (Neuroglide) is a FDA-cleared Class II medical device (K202693) for over-the-counter use for pain.⁸ It mimics manual lymphatic drainage through a pneumatic mat that performs rhythmic inflation and deflation in ascending fashion.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 25-008009

Tools To Detect The Effect Of Hypomethylating Agents And Examination Of Protein Interactions Predicting Response To Therapy In Acute Myeloid Leukemia

Rochester, MN

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Tools To Detect The Effect Of Hypomethylating Agents And Examination Of Protein Interactions Predicting Response To Therapy In Acute Myeloid Leukemia

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

Acute myeloid leukemia (AML) is a heterogeneous clonal disease with significant disease-specific mortality. While most patients (pts) who are eligible for induction chemotherapy achieve complete remission (CR)/CR with incomplete hematologic recovery (CRi), long-term outcomes remain poor, especially in older pts and those unable to withstand intensive therapy. With the relatively recent addition of the doublet of hypomethylating agent (HMA), decitabine or azacitidine, plus BCL2 inhibitor venetoclax to the therapeutic toolbox in AML, especially in older and unfit pts, rates of CR/CRi have improved to about 66% based on phase III data. The doublet seems to exhibit synergism surpassing the efficacy of single-agent venetoclax or HMA therapy. Recent work has shown that azacitidine activates the integrated stress signal pathway to induce expression of the pro-apoptotic BCL2 family members NOXA and PUMA in AML cell lines in vitro and in xenografts. These observations have not been extended to AML pts receiving therapy with HMA/venetoclax. Moreover, it is unclear what happens to interactions involving other BCL2 family members upon treatment with HMA/venetoclax. Our group has previously observed that BAK is constitutively activated in certain AML cell lines and clinical samples, increasing the susceptibility of cells to specific BH3 mimetics and possibly other agents. Our studies have also shown that upregulation of NOXA, e.g., after treatment of AML cells with pevonedistat, displaces BAK from preformed complexes with MCL1. To determine whether induction of NOXA and disruption of other BCL2 family interactions are associated with a favorable outcome in AML treated with HMA/venetoclax, we propose to examine BCL2 family expression and interactions at days 0, 1, and 4-6 of therapy in a cohort of 30 pts with previously untreated AML receiving HMA/venetoclax. Using a combination of Western blotting on whole cell lysates, immunoprecipitation followed by Western blotting, and proximity ligation assays, we will examine dynamic changes in interactions between anti-apoptotic BCL2 family members (BCL2, BCLXL, and MCL1) and pro-apoptotic binding partners, including BAK, BAX, NOXA, BIM, PUMA, and BID. This study will improve our understanding of the factors that determine sensitivity to the HMA/venetoclax doublet, suggest potential mechanisms of resistance for future investigation, and point toward novel three-drug combinations designed to overcome this resistance. We will also use this study to ensure that two different assays developed to detect DNMT1-DNA covalent complexes (one based on mass spectometry and one involving custom-made monoclonal antibodies) can detect DNMT1-DNA covalent complexes in blood samples from patients treated with HMA.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Contact us for the latest status	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 21-010767
Sponsor Protocol Number:
21-010767

Female Patients And Female Partners Of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma (Pap-Op): Prospective Assessment Of HPV Associated Anogenital Pathology

Rochester, MN

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Female Patients And Female Partners Of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma (Pap-Op): Prospective Assessment Of HPV Associated Anogenital Pathology

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to determine the incidence of anogenital infection with high-risk HPV serotypes and HPV-associated anogenital lesions in female patients with newly diagnosed HPV(+)OPSCC and female partners of patients with HPV(+)OPSCC, and compare this with retrospective review of exams and paps obtained during routine well woman checks in Rochester MN.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 22-005420
NCT ID:
NCT06115772
Sponsor Protocol Number:
22-005420

Viscoelastic Parameters Estimation And Imaging For The Assessment Of Axillary Lymph Nodes

Rochester, MN

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Viscoelastic Parameters Estimation And Imaging For The Assessment Of Axillary Lymph Nodes

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

This study is being done to:

• Test an investigational stiffness measurement and imaging method on the lymph node found in the underarm area.

• Compare investigational imaging to sonography images.

• Compare investigational information to FDA approved US elasticity imaging conducted by SuperSonic Imaging (SSI) machine on the same lymph node in your underarm area.

• Compare to FDA approved ultrasound stiffness imaging system (GE Logiq E9)

• Compare to ultrasound images using Alpinion clinical ultrasound platform, FDA approved ECUBE 12and a non-FAD approved ECUBE 12R

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 13-006035
Sponsor Protocol Number:
13-006035

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Search Results 9041-9050 of 11472

Outcome Reflection for Immune Mediated Rejection by Utilizing AI in Cardiac Transplant During Early and Late Echocardiographic Analysis

A Study of a Deep Learning Method for Cardiac CINE MRI

Serum and Portal Vein Extracellular Vesicles in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

A Study Of Intestinal Permeability And Microbiota In HE

Development Of Non-invasive Cell-free DNA To Supplant Invasive Biopsy In Heart Transplantation

ATHNdataset Registry

A Study Of Automated Manual Lymphatic Drainage Therapy For Obstructive Sleep Apnea

Tools To Detect The Effect Of Hypomethylating Agents And Examination Of Protein Interactions Predicting Response To Therapy In Acute Myeloid Leukemia

Female Patients And Female Partners Of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma (Pap-Op): Prospective Assessment Of HPV Associated Anogenital Pathology

Viscoelastic Parameters Estimation And Imaging For The Assessment Of Axillary Lymph Nodes

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