Study to Develop a Linguistically and Culturally Appropriate Adaptation of the Memory Support System (MSS) for Spanish-speaking Hispanics with Mild Cognitive Impairment (MCI) and their Care Partners in the U.S.


About this study

The purpose of this study is to develop a linguistically and culturally- appropriate adaptation of the memory support system (MSS) for Spanish-speaking Hispanics with subjective memory/cognitive complaints or a diagnosis of mild cognitive impairment (MCI) and their care partners in the U.S.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Subjective memory/cognitive complaints or a diagnosis of single or multi-domain MCI.
  • Global score of ≤ 0.5 on the Clinical Dementia Rating (CDR) and scores of ≥ 4 on items six to nine on the Linguistic History Form (CLS) and scores of ≤ 3 on items on the Functional Assessment Scale (FAS), when applicable, from the Spanish language Uniformed Data Set (UDS) from the National Alzheimer’s Coordinating Center’s (NACC).
  • A score of ≥ 115 on the Spanish Translation of the Dementia Rating Scale-Second edition (ST-DRS-2).
  • Having contact with a care partner at least twice a week.
  • Either not taking or stable on nootropic(s) for at least 3 months.

Exclusion Criteria:

  • Visual/hearing impairment and/or history of reading or written inability/disability sufficient to interfere with MSS training.
  • Inclusion in another clinical trial that would exclude participation; subject will be considered for participation at the end of such a trial or as appropriate.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Octavio Santos, Ph.D.

Closed for enrollment

More information


Publications are currently not available

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