Elena Anna (Eleanna) O. De Filippis, M.D., Ph.D.

To determine whether EOS recruitment in AT is impaired during obesity. Therefore, we hypothesize that chronic, low-grade inflammation of AT initiates epigenetic modifications in EOS and/or in AT, thereby impairing the recruitment of eosinophils.

This study is being done to better understand the relationship between inflammation in your AT, abnormal deposition of fat around your liver and how this affects its appearance and function and ultimately insulin resistance.

The purpose of this study is to find the inheritable changes in genetic makeup that are related to the development of type 2 diabetes in Latino families.

This study is being done to better understand the relationship between inflammation and insulin resistance in your Adipose (fat) Tissue .

This protocol is being conducted to determine the mechanisms responsible for insulin resistance, obesity and type 2 diabetes.

There are two purposes for this project.

• One purpose of this project is to develop information about Latinos in the Maricopa County area who may be interested in participating in future research studies about health.

• A second purpose is that researchers at Mayo Clinic are developing a new research resource called a Biobank. A Biobank is a collection of blood samples and other information. Participants in the Biobank provide samples of blood, complete a health questionnaire, and allow access to medical records now and in the future. A Biobank is as a library for researchers; instead of having to look for volunteers for each new project, researchers can use samples from the Biobank as well as share information already collected.