Understanding the Relationship Between Inflammation and Insulin Resistance in the Adipose Tissue


About this study

This study is being done to better understand the relationship between inflammation and insulin resistance in your Adipose (fat) Tissue .

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Lean, healthy person with a body mass index (BMI) of 25 or less.
  • Or if obese, BMI between 30 and 50.
  • Non-diabetic.
  • Lean healthy controls will not be on any medication and will be undergoing elective abdominal surgery excluding those involving acute inflammation (i.e., acute cholecystitis, bowel perforation, or diverticulitis).
  • Taking no medications affecting glucose metabolism or lipid metabolism.
  • Subjects will be identified from a pool of patients undergoing an elective abdominal surgical procedure such as inguinal hernia repair, laparoscopic Nissen fundoplication, planned cholecystectomy, but also bariatric surgery.
  • Volunteers will not be taking corticosteroid therapy or have a history of asthma, COPD or atopic syndrome.
  • All subjects will undergo a medical history intake and a physical examination followed by an OGTT to confirm normal glucose.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Elena Anna De Filippis, M.D., Ph.D.

Closed for enrollment

Contact information:

Zane Ioli



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