A Study to Analyze the Effect of Obesity on Eosinophil (disease fighting white blood cell) Recruitment in Human Adipose Tissue

Overview

About this study

To determine whether EOS recruitment in AT is impaired during obesity. Therefore, we hypothesize that chronic, low-grade inflammation of AT initiates epigenetic modifications in EOS and/or in AT, thereby impairing the recruitment of eosinophils.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Subjects with ages ranging between 18-80 years.
  • Lean subjects will have a BMI of 25 or less.
  • Gender specific normal body fat.
  • Subjects taking no immunomodulating medication.
  • Subjects undergoing elective abdominal surgery (either laparotomy or laparoscopic approach) for any procedure with the exclusion of those involving acute inflammation (i.e., acute cholecystitis, bowel perforation or diverticulitis).
  • Obese, non-diabetic subjects will have a BMI between 30 and 50.
  • Obese, non-diabetic subjects will be taking no medications affecting glucose metabolism or lipid metabolism.
  • These subjects will be identified from a pool of patients undergoing an elective abdominal surgical procedure such as inguinal hernia repair, laparoscopic Nissen fundoplication, planned cholecystectomy, and bariatric surgery.
  • Subjects will not be receiving corticosteroid therapy.
  • Subjects will not have a history of asthma, COPD or atopic syndrome.
  • Subjects will also not be taking any leukotriene receptor antagonist acting medications (ex. Montelukast).
  • All subjects will be self reported non-smokers.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Elena Anna De Filippis, M.D., Ph.D.

Open for enrollment

Contact information:

Emily Branch B.S.

(480)301-9392

Branch.Emily@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20480539

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