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Clinical Studies


  • Development of Liquid Biopsy for Pediatric Brain Tumors Rochester, Minn.

    The purpose of this study is to confirm detection of the H3K27M mutation in patient biofluids (CSF, blood, urine, saliva) and uncover the molecular histone (alkaline protein) profile of H3K trimethylation and H3S phosphorylation in the circulating nucleosomes isolated from the biofluids of patients with H3K27M tumors.

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  • Cell Biological Interrogation of Patient-derived AVM Cell Lines (AVM) Rochester, Minn.

    The purpose of this study is to generate endothelial and smooth muscle cell lines from patients with brain arteriovenous malformations (AVM)s for subsequent use in cell culture (and eventually animal models) in order to delineate the underlying cell, molecular, genetic, and epigenetic features of brain AVMs.

  • STAT3 Expression in Patients with Diffused Intrinsic Pontine Glioma (DIPG) Rochester, Minn.

    The purpose of this study is to verify the gene array data by examining the protein expression in brain tissue of diffuse intrinsic pontine glioma (DIPG) patients compared to normal healthy subjects using western blot.

  • The Park Reeves Syringomyelia Research Consortium Rochester, Minn.

    The purpose of this registry is to use a comprehensive database to study syringomyelia and chiari 1 malformation, the natural history, and clinical course following treatment in a large number of patients, and use advanced magnetic resonance imaging, CT and x-ray imaging to study the pathophysiology of the condition.