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Clinical Studies


  • Development of Liquid Biopsy for Pediatric Brain Tumors Rochester, Minn.

    The purpose of this study is to confirm detection of the H3K27M mutation in patient biofluids (CSF, blood, urine, saliva) and uncover the molecular histone (alkaline protein) profile of H3K trimethylation and H3S phosphorylation in the circulating nucleosomes isolated from the biofluids of patients with H3K27M tumors.

  • The Park Reeves Syringomyelia Research Consortium Rochester, Minn.

    The purpose of this registry is to use a comprehensive database to study syringomyelia and chiari 1 malformation, the natural history, and clinical course following treatment in a large number of patients, and use advanced magnetic resonance imaging, CT and x-ray imaging to study the pathophysiology of the condition.

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  • Investigation of Regulatory Genes in Pathophysiology of Craniosynostosis Rochester, Minn.

    The purpose of this study is to collect tissue (during the initial procedure only) that is surgically removed (and routinely discarded at Mayo Clinic) from CS patients. Portions of the tissue will be embedded in plastic for histological and histomorphometric analysis. A small portion of the tissue will be used for outgrowth cultures to isolate cells. Nucleic acid and protein will be extracted from the remaining portions of the tissue and/or isolated cell lines to examine candidate genes and their role in the disease process.

  • Posterior Fossa Decompression with or without Duraplasty for Chiari Type I Malformation with Syringomyelia Rochester, Minn.

    The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in those who have Chiari malformation type I and syringomyelia.

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