Cell Biological Interrogation of Patient-derived Arteriovenous Malformation Cell Lines


About this study

The purpose of this study is to generate endothelial and smooth muscle cell lines from patients with brain arteriovenous malformations (AVM)s for subsequent use in cell culture (and eventually animal models) in order to delineate the underlying cell, molecular, genetic, and epigenetic features of brain AVMs.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult and pediatric patients.
  • Undergoing surgical resection of their brain AVM.
  • Have not undergone previous stereotactic radiosurgery or endovascular embolization.  

Exclusion Criteria:

  • Have undergone previous stereotactic radiosurgery or endovascular embolization.

Eligibility last updated 9/7/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

David Daniels, M.D., Ph.D.

Open for enrollment

Contact information:

Bambi Wessel

(507) 538-1424


More information


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