Marius N. Stan, M.D.

The purpose of this study is to examine the effects of RVT-1401 versus placebo on proptosis responder rate at week 7, and to assess the safety and tolerability of RVT-1401 in patients with active, moderate to severe Graves' Ophthalmopathy (GO).

The purpose of this study is to evaluate the efficiency of Radiofrequency ablation (RFA) therapy to treat papillary thyroid carcinoma.

The purpose of this study is to analyze the changes in serum thyroid hormone levels in amiodone-induced thyroiditis (AIT) patients after radiofrequency ablation (RFA) therapy on a portion of thyroid parenchyma in order to safely decrease thyroid hormone levels into the normal range with resolution of thyrotoxicosis.

The purpose of this study is to evaluate the safety and effectiveness of CFZ533 following 12 weeks of treatment in patients with Graves' disease.

This study is being done to see if better therapies can be developed to treat Graves’ disease, using new laboratory assays

Will teriparatide ( Forteo) shorten the length of hospitalization post thyroidectomy in patients with symptomatic hypoparathyroidism

The purpose of this study is to determine the placental D3 activity in a woman with RTH and compare to women without RTH because we believe this may be a potential mechanism which limits fetal thyroid hormone exposure.

The study will try to answer the question of whether early treatment with levothyroxine at 4 weeks after radioactive iodine for Graves' disease will prevent overt hypothyroidism (low thyroid hormone levels).

The purpose of this study is:

1. To create a biospecimen and data resource of autoimmune thyroid disease patients and a control group of healthy volunteers for use in future research studies.Subjects will include:
   1. All newly diagnosed cases of autoimmune thyroid disease entities (Hashimoto’s thyroiditis, Graves’ disease, subacute thyroiditis, painless/lymphocytic/post-partum thyroiditis, Graves’ orbitopathy and Pretibial myxedema) seen at Mayo Clinic Rochester within 12-18 months of diagnosis.
2. To utilize the cultured orbital fibroblasts for analyzing the role of IGF1r in GO pathophysiology and the potential role PAPP-A can play in that cascade, based on Dr. Conover’s research in the field.
3. Development of improved diagnostic testing for autoimmune thyroid disease.