Thyroid Autoimmunity Biobank

Overview

About this study

The purpose of this study is:

  1. To create a biospecimen and data resource of autoimmune thyroid disease patients and a control group of healthy volunteers for use in future research studies.Subjects will include:
    1. All newly diagnosed cases of autoimmune thyroid disease entities (Hashimoto’s thyroiditis, Graves’ disease, subacute thyroiditis, painless/lymphocytic/post-partum thyroiditis, Graves’ orbitopathy and Pretibial myxedema) seen at Mayo Clinic Rochester within 12-18 months of diagnosis.
  2. To utilize the cultured orbital fibroblasts for analyzing the role of IGF1r in GO pathophysiology and the potential role PAPP-A can play in that cascade, based on Dr. Conover’s research in the field.
  3. Development of improved diagnostic testing for autoimmune thyroid disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Graves' Disease
    • ≥18 years of age
    • TSH < 0.1 mIU/L
    • RAI scan and uptake: symmetric bilateral and>% LLN
    • Total T4 > 11.7 mcg/dL /total T3 > 200 ng/dL or Free T4 level: ≥1.7 ng/dL
  • Painless Thyroiditis
    • ≥18 years of age
    • TSH < 0.1 mIU/L
    • Thyroid uptake < 3%
    • Total T4 > 11.7 mcg/dL /total T3 > 200 ng/dL or Free T4 level: ≥1.7 ng/dL
    • Absence of iodine exposure, neck pain
    • Note: immunomodulatory therapy should be mentioned clinically
  • Subacute Thyroiditis
    • ≥18 years of age
    • TSH < 0.1 mIU/L
    • Thyroid uptake < 3%
    • Total T4 > 11.7 mcg/dL /total T3 > 200 ng/dL or Free T4 level: ≥1.7 ng/dL
    • Absence of iodine exposure
    • Presence of neck pain, elevated ESR > ULN for age
    • Note: immunomodulatory
  • Hashimoto’s Thyroiditis
    • ≥18 years of age
    • TSH > 4.2 mIU/L
    • TPO antibodies >9 IU/L or ULN for the assay
    • US pattern or cytology or pathology consistent with HT
  • Graves’ Orbitopathy
    • ≥18 years of age
    • Presence of manifestations for GO, both inactive and active (CAS≥3)
    • History of autoimmune thyroid disease
    • CT/MRI consistent w/ GO
  • Healthy Controls Serum
    • ≥18 years of age
    • No personal or family history of thyroid disease
    • Normal TSH cascade
    • No use of medication known to affect thyroid function
    • Normal thyroid exam
  • Orbital Controls
    • ≥18 years of age
    • Patients that are scheduled to undergo orbital decompression for non-autoimmune conditions (e.g. normal pressure hydrocephalus, trauma etc.)
  • Pretibial Myxedema
    • ≥18 years of age
    • Diagnosis of PTM on clinical grounds, confirmed in Dermatology 

Exclusion Criteria:

  • Graves' Disease
    • Prior treatment with thyroidectomy or radioiodine or concurrent treatment with anti-thyroid drugs (preferred newly diagnosed patients).
    • Pregnancy
  • Painless Thyroiditis
    • Pregnancy
  • Subacute Thyroiditis
    • Pregnancy
  • Hashimoto’s Thyroiditis
    • Absence history of RAI therapy or external radiation to thyroid; absence thyroid cancer history
    • Pregnancy
  • Graves’ Orbitopathy
    • History of radiation to orbits; immunomodulatory therapy except oral steroids (>4 weeks off)
    • Pregnancy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Marius Stan, M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Paula Giesler R.N.

(507)255-8345

Giesler.Paula@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20425085

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