A Study to Evaluate Treatment of Papillary Thyroid Carcinoma with Radiofrequency Ablation


About this study

The purpose of this study is to evaluate the efficiency of Radiofrequency ablation (RFA) therapy to treat papillary thyroid carcinoma.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • Adult patients ≥ 18 years of age and ≤ 85 years of age.
  • Nodule with Papillary thyroid carcinoma meeting the below criteria: 
    • Diagnosed by FNA cytology;
    • Size < 1.5 cm;
    • Non-surgical therapy is considered acceptable by the treating physician;
    • Radiology evaluation deems the lesion amenable to RFA therapy with minimal risk of complication.

Exclusion Criteria: 

  • Clinical evidence for a multifocal papillary thyroid malignancy.
  • Clinical evidence for local or distant metastatic disease. 
  • Pregnancy.
  • Vocal cord paralysis on contralateral side. 
  • Coagulopathy or patients on anticoagulation therapy.
  • Patients with prior neck surgery or neck radiation. 
  • Patients with neck anatomy that precludes easy access by RFA. 
  • Patients with comorbidities deemed too high of a risk for general anesthesia.
  • Treatment with another investigational drug or intervention (within 6 weeks of planned RFA). 
  • Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Marius Stan, M.D.

Open for enrollment

Contact information:

Vishakantha Murthy M.B.A., CCRP

(919) 265-9986


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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