Faculty

James F. Meschia, M.D.

Clinical Studies

A Phase II Double-Blinded Placebo Controlled Individual Subject Stepped Wedge Clinical Trial Evaluating the Safety and Efficacy of Fremanezumab for Migraine in Adult CADASIL Jacksonville, Fla.
The purpose of this study is to to assess the effectiveness of fremanezumab on decreasing migraine-related disability as measured by the MIDAS 12 and headache intensity by the HIT-6.44.
Detection of Vascular and Inflammatory Plasma Biomarkers in Patients Diagnosed with Obstructive Sleep Apnea and MRI-defined Cerebral Small Vessel Disease Jacksonville, Fla.
The purpose of this study is to evaluate plasma biomarkers of vascular function and inflammation in patients with newly-diagnosed Obstructive Sleep Apnea (OSA) and pre-existing imaging evidence of Cerebral Small Vessel Disease (CSVD).

Genetic Variation, Stress, and Functional Outcomes After Stroke Rehabilitation Jacksonville, Fla.
The purpose of this research study is to examine how certain genes and lifetime and ongoing stress may impact rehabilitation and recovery after stroke.
Genomic Variation in Modeling Cerebral Small Vessel Disease Jacksonville, Fla.
The aim of this study is to deeply phenotype adult patients and healthy volunteers with varying degrees of sporadic CNS small vessel disease (deep white matter Fazekas scores of 0 to 3). This would be a stage 1 phenotyping exercise of CNS small vessel disease.