Genetic Variation, Stress, and Functional Outcomes After Stroke Rehabilitation


About this study

The purpose of this research study is to examine how certain genes and lifetime and ongoing stress may impact rehabilitation and recovery after stroke.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Age ≥18 years
  2. Stroke that is ischemic in etiology or intracerebral hemorrhage, onset 2-10 days prior, and radiologically confirmed on either CT or MRI.
  3. Able to provide responses to study assessments, determined by whether subjects can answer 2 simple screening questions.
  4. Able to communicate in English.
  5. Reasonable expectation patient can participate in study visits through month 12.
  6. Reasonable likelihood that patient will receive standard of care rehabilitation therapy after discharge.

Exclusion Criteria: 

  1. Expected survival is <1 year.
  2. Moderate-severe disability prior to stroke (pre-stroke modified Rankin scale score >2).
  3. Had a major brain or nerve disease that was active immediately prior to the stroke.
  4. Was hospitalized for a mental health problem in the prior 24 months.
  5. History of a symptomatic stroke in the 90 days prior to the index stroke.
  6. History of moderate-severe traumatic brain injury, operationally defined as a traumatic event accompanied by loss of consciousness for >30 minutes.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

James Meschia, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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