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  • Human Safety and Feasibility Study of Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy Rochester, Minn.

    The purpose of this study is to track seizure occurrence, seizure probability, behavioral state, cognition, and mood using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S & PAD) provides intracranial EEG (iEEG) sensing, electrical brain stimulation, and machine learning algorithms running on the RC+S and PAD that will be coupled with electrical brain stimulation (EBS) to prevent seizures and improve quality of life in patients with epilepsy

  • Multiscale EEG Dynamics Rochester, Minn.

    The purpose if this study  to combine state of the art cerebral signal processing techniques and localization methods with intracranial electrode recordings to investigate the interaction of local hippocampal and neocortical networks with distributed brain activity.

  • Temporal Dynamics of Mood Symptoms in Epilepsy Patients Rochester, Minn.

    The purpose of this study is to track neuropsychiatric symptoms in patients with epilepsy.

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  • 7 Tesla Brain MRI in Inadequately Localized Refractory Partial Epilepsy Rochester, Minn.

    This study will use powerful 7T MRI scanning to find very small brain lesions that cause partial epileptic seizures.These small lesions can be missed by current MRI scanners. When a  neurosurgeon can find and remove the small area where the seizure starts, it is often possible to cure the epilepsy.

  • EEG Dynamics Using High Density Scalp and Intracranial Electrodes Rochester, Minn.

    In this study the EEG (Brain wave activity) will be recorded while you perform tasks on a laptop computer. The purpose of this research is to look for changes in the EEG that occur with performing mental tasks, and to study the part of the brain.

  • Imaging and Systemic Markers in Patients with Epilepsy Rochester, Minn.

    The purpose of this study is to investigate if blood and/or MRI markers of inflammation and immune system activation may show changes in relation to when you have a seizure, and to noninvasively detect seizure related structural and functional alterations in acute seizure by MRI.

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