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Clinical Studies


  • Biomarker Target Stimulation Rochester, Minn.

    The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

  • Early Feasibility Study of Thalamic Stimulation to Prevent Impaired Consciousness in Epilepsy (START) Rochester, Minn.

    The purpose of this study is to investigate the feasibility and safety of thalamic CL stimulation in restoring consciousness in epilepsy patients.

  • Human Safety and Feasibility Study of Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy Rochester, Minn.

    The purpose of this study is to track seizure occurrence, seizure probability, behavioral state, cognition, and mood using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S & PAD) provides intracranial EEG (iEEG) sensing, electrical brain stimulation, and machine learning algorithms running on the RC+S and PAD that will be coupled with electrical brain stimulation (EBS) to prevent seizures and improve quality of life in patients with epilepsy

  • Morpheus – Manipulating and Optimizing Brain Rhythms for Enhancement of Sleep (Morpheus) Rochester, Minn.

    The aim of this feasibility study is to investigate whether we can improve sleep quality in patients who have DBS devices implanted for existing neurological indications by delivering targeted stimulation patterns during specific stages of sleep using their existing DBS device. We will only use electrical stimulation frequencies that have been proven to be safe for patients. We will perform these studies in patients admitted to the hospital in order to examine the structure and quality of sleep as well as how alert patients are when they wake up, while also monitoring physiological markers such as brainwave activity, heart rate and blood pressure.  Upon awakening, we will ask the patients to provide their subjective opinion of their sleep and complete some simple tests to see how alert they are compared to a night of no electrical stimulation.

    We hope that our study will open new ways of optimizing sleep in patients with neurological disease who are implanted with DBS device.  We also believe tha tour findings will broaden the understanding of how the activity of deep brain areas influences sleep and alertness.


  • Multiscale EEG Dynamics Rochester, Minn.

    The purpose if this study  to combine state of the art cerebral signal processing techniques and localization methods with intracranial electrode recordings to investigate the interaction of local hippocampal and neocortical networks with distributed brain activity.

  • Temporal Dynamics of Mood Symptoms in Epilepsy Patients Rochester, Minn.

    The purpose of this study is to track neuropsychiatric symptoms in patients with epilepsy.

Closed for Enrollment