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Clinical Studies


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  • A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients Rochester, Minn.

    To establish the feasibility of a tool that monitors and motivates people with COPD to complete training in mindful pursed-lip breathing to enhance pulmonary rehabilitation at home.

  • A Pilot Study of Inspiratory Muscle Training for Patients Undergoing Esophageal Surgery Rochester, Minn.

    The purpose of this study is to get definite evidence for the effectiveness of a short preoperative inspiratory muscle training protocol on the level of sickness and recovery of patients who are having the surgical removal of a portion of the esophagus.

  • Effect of Meditation on Emotional Buoyancy and Burnout in Physicians Rochester, Minn.

    This study aims to establish whether brief daily meditation will positively impact physicians’ emotional buoyancy and overall well-being. Secondary outcomes include perceived happiness, physician burnout, and physical activity/sleep quality to be measured by an activity monitor. The latter will be measured to provide a more comprehensive picture of physician well-being. This pilot study also seeks to establish the feasibility of using the Muse™ device to assist novice meditators in building and strengthening their practice.

  • Feasibility of a Multi Component Intervention in Patients with Severe Dyspnea and Obesity Rochester, Minn.

    The purpose of this study is to define the feasibility and effectiveness of a multi-component intervention aimed at decreasing perception of dyspnea in participants with lung disease who are obese.

  • Home Pulmonary Rehabilitation for COPD Rochester, Minn., Jacksonville, Fla.

    While pulmonary rehabilitation provides benefits to people with COPD, only 1.5% have access to pulmonary rehabilitation each year. The main barriers are related to travel and transportation. This protocol will evaluate the effect of a home-based rehabilitation system on quality of life and steps. The system allows for monitoring by a health care system. A health coach will review the data and provide coaching to facilitate behavioral change and self-efficacy. Patients will be randomized to 1 of 2 groups.

  • Home-based Health Management of COPD Patients Rochester, Minn.

    Regular physical activity has been found to be important in maintaining health and well-being in people with COPD. The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more physically active in their daily lives.

  • Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

    The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more physically active in their daily lives.


  • L-Carnitine Supplementation With and Without Health Coaching for Fatigue in Patients With Chronic Obstructive Pulmonary Disease (COPD) (LC4COPD) Rochester, Minn.

    We hypothesize that supplementation with L-carnitine that is available both as an FDA-approved therapy for primary carnitine deficiency, as well as widely available as an over-the-counter ergogenic aid will improve wellbeing and function measured by questionnaires in patient with chronic obstructive pulmonary disease (COPD). We further hypothesize based on our review of literature that addition of health coaching (HC) to L-carnitine will yield greater gains.

  • Mindfulness to Mitigate the Effect of Anxiety-depression-fear in COPD Rochester, Minn.

    People with COPD have a greater risk for symptoms of depression, anxiety, and fear of breathlessness. Those emotions are independently associated with lower physical activity, poorer quality of life, and higher hospitalization and exacerbations; all independent predictors of survival and costs. There is a lack of treatment options to be routinely used in primary clinics for patients with COPD. Systematic reviews suggest that interventions that promote an accepting mode of response, such as mindfulness, might be more appropriate and effective for managing psychological distress in COPD patients, especially breathing-related anxiety. Hypothesis: A home-based 8-week Mindfulness-Based Stress Reduction (MBSR) for COPD targeted to individuals with symptoms of depression, anxiety, or fear of breathlessness delivered by a mindfulness coach using a combination of in-person sessions and remote video call sessions will be effective in improving emotional and overall quality of life, and measured physical activity.

  • Multicomponent Intervention to Decrease COPD-related Hospitalizations Rochester, Minn.

    The investigators' proposed study is a randomized controlled trial that will prospectively examine the effect of a multicomponent intervention on the rate of hospitalizations, daily physical activity, self efficacy and health status in patients who have COPD and have been hospitalized because of a COPD exacerbation.

    In the study, a convenience sample of patients recently hospitalized for a COPD exacerbation, who meet the selection criteria and agree to participate will be randomized to receive one of the following at the time of hospital discharge: (1) the current standard of care plus a multicomponent intervention (counselor + pulmonary rehabilitation) or (2) the current standard of care without the intervention.

    This study plans to test the following hypotheses: (1) The primary outcome of the study to be the composite endpoint of death or COPD hospitalization (2) Time to first rehospitalization will be shorter in the intervention group than the control group (3) At follow-up, the physical activity level measured in terms of the average number of steps and active energy expenditure will be higher in the intervention group than in the control group.

  • Pulmonary Rehabilitation Before Lung Cancer Resection Rochester, Minn., Jacksonville, Fla.

    This study seeks to study the effectiveness of a short mindfulness based pulmonary rehabilitation program prior to a surgical resection in patients with lung cancer and severe Chronic Obstructive Lung Disease (COPD).

  • Remote Monitoring with Health-Coaching for Lifestyle Changes in Patients with Lung Cancer Related Fatigue Rochester, Minn.

    The purpose of this study is to test the effectiveness of a remote monitoring program with health coaching for patients with cancer related fatigue.  

    The primary objective is to assess the effect of the remote-monitoring program on patient reported fatigue by administering the Brief Fatigue Inventory and the Cancer Fatigue Scale/ MFSI-SF. Secondary objective is to assess the effect of the program on quality of life by administering the LASA questionnaire.