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A Study Of Characterization Of Periprosthetic Joint Infection Tissues
Rochester, MN
The purpose of this study is to characterize and compare the local and systemic immune landscape in patients with PJI versus those with non-infected arthroplasty failure (NIAF) by performing high-dimensional immune profiling on synovial fluid, residual peri-implant tissue, and peripheral blood.
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Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
Rochester, MN
The primary aims of this study are to determine whether extended oral prophylactic antibiotics after primary total joint arthropasty (TJA) decreases the incidence of periprosthetic joint infection (PJI) in a high-risk patient population, and to determine whether extended oral prophylactic antibiotics after primary TJA decreases the incidence of surgical wound complications in a high-risk patient population.
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Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
Rochester, MN; Jacksonville, FL
The purpose of this study is to evaluate two different standards of care to see if the single Double Debridement, Antibiotics and Implant Retention (DAIR) protocol is non-inferior to planned double-DAIR protocols for acute Periprosthetic Joint Infection (PJI) after primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). Additionally, effectiveness of treatment in terms of infection eradication and cost comparisons will be addressed.