A Study to Determine if an Early Alert Checklist Can Help Prevent Severe Organ Damage and Death in Patients with Acute Respiratory Failure
Severe acute respiratory failure requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure, high mortality, and functional impairment. The purpose of this study is to improve the outcomes of patients at high risk with early intervention using an electronic medical records checklist aimed at preventing the lung injury that commonly leads to organ failure.
Study to Determine Safety and Effectiveness of Ascorbic Acid, Corticosteroids, and Thiamine in Treating Sepsis and Septic Shock
The purpose of this study is to determine whether the combination of Ascorbic Acid (Vitamin C), Thiamine (Vitamin B1), and Corticosteroids improves the trajectory of organ failure and reduces mortality in patients with sepsis and septic shock as compared to placebo.
Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19 (enrollment by invitation only)
Phase 2: The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with severe COVID-19.
Phase 3: The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with severe or critical COVID-19.