A Study to Determine if an Early Alert Checklist Can Help Prevent Severe Organ Damage and Death in Patients with Acute Respiratory Failure


About this study

Severe acute respiratory failure requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure, high mortality, and functional impairment. The purpose of this study is to improve the outcomes of patients at high risk with early intervention using an electronic medical records checklist aimed at preventing the lung injury that commonly leads to organ failure.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Adult patients aged > 18 in the hospital
  • Identified as being at high risk for developing severe acute respiratory failure requiring prolonged mechanical ventilation

Exclusion Criteria

  • Is chronically ventilated
  • Have DNI orders on hospital admission
  • In an area of the hospital that is unable or unwilling to participate

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Vitaly Herasevich, M.D., Ph.D.

Closed for enrollment

Contact information:

Yue Dong M.D.

(507) 255-4407


More information


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