Displaying 10 studies

  • A Study to Develop a Horizontal Axial Movement Test for Use Before and After Shunt Treatments in Patients who have Normal Pressure Hydrocephalus Jacksonville, FL

    The purpose of this study is to develop a test for axial movements in the horizontal position, then determine if it improves after the diagnostic tap test and can be used as a prognostic indicator for shunt surgery.

  • Clinical Outcomes Following Shunting for Idiopathic Normal Pressure Hydrocephalus (iNPH) Rochester, MN

    The purpose of this study is to collect data to objectively monitor the clinical outcomes of patients following CSF shunting for the treatment of idiopathic normal pressure hydrocephalus in order to optimize the surgical care of patients with this disease.

  • MR Elastography of Hydrocephalus Rochester, MN

    We are doing this research study to develop and test the effectiveness of a new imaging technique called magnetic resonance elastography (MRE). This technique measures the stiffness (mechanical properties) of the brain and cerebral spinal fluid.

  • A Study to Establish a Registry for Treatment of Post-hemorrhagic Hydrocephalus in Neonates Rochester, MN

    The purpose of this study is to establish a prospective, standardized data collection for the patients who undergo surgical treatment of progressive post-hemorrhagic hydrocephalus in neonates with the focus on comparing neuroendoscopic lavage (NEL) with other standard treatment options such as external ventricular drainage (EVD), ventricular access device (VAD) and ventricular subgaleal shunt (VSGS).

  • Prognostic value of Aβ Imaging in NPH Prior to Shunt Placement Jacksonville, FL

    In this pilot study the investigators shall prospectively in a blinded fashion evaluate with AB PET and CSF AB42 and tTau or pTau in patients committed to shunt surgery and then investigate the relationship of these biomarkers with outcome on gait, cognition and urinary control improvement in the short term (3 months) and long term (1 year). The imaging agent will be provided by AVID.

    Furthermore the study will standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.

  • Collection of Discarded Cerebrospinal Fluid for Research Purposes Rochester, MN

    The purpose of this study is to collect and store cerebrospinal fluid (CSF)from patients with normal CSF.  This stored CSF will be used in the future as a culture media to better understand how therapeutic cells delivered into the CSF will behave. 

  • Cerebrospinal Fluid and Tumor Samples from Patients with Vestibular Schwannomas Rochester, MN

    The goal of this study is to correlate protein content in vestibular schwannomas and cerebrospinal fluid to patient outcomes, imaging findings, and other relevant clinical endpoints in patients who presented with both this tumor type and hydrocephalus.

  • A Study to Evaluate MR of CSF Dynamics Rochester, MN

    The purpose of this study is to evaluate changes in CSF dynamics (e.g., velocity, flow rate) between patients with normal pressure hydrocephalus and healthy controls, as well as patients with other dementia disorders.

  • A Study to Establish an Enterprise Neurosurgery Biobank Rochester, MN

    The purpose of this study is to expand biobanking to neurosurgical disorders where similar protocols do not exist in the institution (e.g., neurovascular disease) and complement existing biobanking protocols where they do exist (e.g., neuro-oncology, skull base tumors, degenerative spine). 

  • A Study of the Effects of Cytochrome P450 Enzyme on the Metabolism of Nimodipine after Aneurysm Jacksonville, FL

    The purpose of this study is to determine if cytochrome P450 (CYP) enzyme family variants alter the body's metabolism of nimodipine after Aneurysmal Subarachnoid Hemorrhage (aSAH), and if actual levels of nimodipine correlate with clinical events and patient outcomes.


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