Clinical Trials

Hemolytic uremic syndrome (HUS)

Displaying 3 studies

Using C3d Staining to Identify Complement-mediated Hemolytic Uremic Syndrome in Kidney Biopsies Rochester, MN

The aim of this project is to evaluate whether kidney biopsy tissue will stain positive for C3d under immunofluorescence in patients who had renal thrombotic microangiopathy (TMA) caused by atypical hemolytic uremic syndrome (aHUS) and to study if that could offer a diagnostic value.
Evaluation of Laboratory Methods for Detecting Auto Antibodies to Complement Proteins Rochester, MN

The goal of this study is to validate testing to be performed in the clinical immunology lab and have a source of positive patient sera.

These tests include:
1. Auto antibodies to Factor H
2. C3 Nephritic Factor
3. Auto antibodies to C1q
4. Auto antibodies to C1INH
Mutational Analysis of Alternative Pathway Complement Regulatory Proteins Rochester, MN

The purpose of this study is to develop and validate full gene-sequencing assays or known mutation sequencing assays for the evaluation of patients with suspected alternative pathway complement defects.