Evaluation of Laboratory Methods for Detecting Auto Antibodies to Complement Proteins


About this study

The goal of this study is to validate testing to be performed in the clinical immunology lab and have a source of positive patient sera.

These tests include:

  1. Auto antibodies to Factor H
  2. C3 Nephritic Factor
  3. Auto antibodies to C1q
  4. Auto antibodies to C1INH

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:       

  • Patients (6 months old and older) who are suspected to have defects in there complement components. 
    • This includes patients who are suspected to have atypical HUS, Dense Deposit Disease (DDD) and C3 related glomerulonephritis. 

Exclusion Criteria:      

  • Less than 6 months old        

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

David Murray, M.D., Ph.D.

Open for enrollment

Contact information:

Brittany Price



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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