Clinical Trials

The purpose of this study is to design and develop a wearable amplification device with the capability of an extended high frequency range for improved fidelity, directionality, noise cancellation, and surround sound. 

Noninvasive electrostimulation of the cochlea has notable benefits for normal hearing and hearing-impaired individuals that extend well-beyond conventional acoustic and bone conducted enhancements of sound.  Although the technique has been known since the 19th century little clinical attention or application of the technique has occurred, particularly related to a wearable technology for individual use.  

The purpose if this study is to determine if an electrical audiometer provides the same, better or poorer evaluation of the hearing in patients with a Bone Anchor.

The purpose of this proposed study is to design a psychometrically valid measure of hearing handicap for the pediatric population.

The purpose of this study is to determine if the use of newly designed investigational iPad application hearing test using noise cancelling headphones to obtain hearing thresholds provides comparable hearing thresholds that can be obtained in a traditional hearing test approach and setting.

The purpose of this study is to establish whether exposure to 3.0T MRI acoustic noise can induce temporary or permanent hearing threshold shifts or otoacoustic emissions amplitude shifts in patients using the currently accepted routine hearing protection. 

The purpose of this study is to determine if adults using the MedEL Flex 28 cochlear implant derive greater benefit from temporal cues when they are coded by fewer numbers of apical electrodes.

This study aims to demonstrate that the investigational drug AUT00063 is effective and safe in the treatment of age-related hearing loss.

The purpose of the study is to evaluate performance of the Acclaim Cochlear Implant System (“System”) and determine what design changes, if any, are required to optimize performance prior to a pivotal study.

The purpose of this study is to evaluate how the benefit obtained from using a directional microphone like StereoZoom in noise varies with location of the speech source (functional directionality).

The purpose of this study is to analyze clinical and audiological outcomes in a large cohort of cochlear implant recipients implanted at the Mayo Clinic since its initiation in 1982.

Aims, purpose, or objectives:

1) Develop hypotheses related to how the human genome and genetic variants affect hearing loss in children and adults.

2) Understand phenotypes of hearing loss on a deeper level by combining and analyzing information from audiometric, genetic, and radiologic data.

3) Explore genetic variants with an unknown significance to develop an understanding of their potential significance and explore other genes may influence an individual's hearing ability.

The purpose of this study is to determine if lay persons and non-physician hearing healthcare providers (e.g. audiologists) can detect ear disease using focused questionnaires (Consumer Ear Disease Risk Assessment [CEDRA] & audiologist based Ear Disease Risk Assessment tool [PEDRA])? The overarching goal of this work is to decrease the cost and increase accessibility of hearing aids and related hearing healthcare services while protecting consumers from the consequences of unrecognized ear disease. In so doing, we will also decrease the cost burden to the overall healthcare system by encouraging only those consumers with high risk of ear disease to seek ...

The purpose of this study is to determine if aural rehabilitation adds measurable benefit and participant satisfaction to a cochlear implant recipient's overall treatment. Also, the study is designed to compare the efficacy of a commercially available aural rehabilitation program (LACE) and an electronic program which takes advantage of a traditional form of auditory training (NOOK) for cochlear implant users.

This study is being done to learn more about the development of the auditory skills in children with bilateral cochlear implants.

The goal of this study is to identify new knowledge that will be used as the basis for a larger scale future study. This study will compare two groups of subjects with HL: those who have otologic signs/symptoms and those who do not.

The purpose of this study is to evaluate available tablet-based technology that can be easily used to screen and monitor patients for the detection of hearing loss in a quiet, clinic setting.

The purpose of this study is to demonstrate the safety and efficacy of the fully implanted Acclaim® cochlear implant for the treatment of severe to profound sensorineural hearing loss.

The specific aim of this work is to optimize consumer and non-physician detection of ear disease.

Current United States Food and Drug Administration (FDA) policies for adults seeking to purchase hearing aids balance two potentially conflicting healthcare objectives: (1) ensure public safety by detecting sinister ear disease prior to hearing aid purchase, and (2) make hearing aids and other hearing healthcare services more affordable and available. Two disease surveillance policies have evolved, reflecting this dichotomy. The FDA preferred surveillance method requires that consumers obtain a pre-hearing aid purchase medical evaluation. This is assumed to provide optimal disease detection - at the potential cost of decreased affordability and availability of hearing healthcare services. Although formally discouraged, consumers ...

The primary objective of this study is to determine the hearing preservation advantage, defined as the increased chance of preservation of residual hearing (i.e., low frequency pure tone average ≤ 80 dB HL), of ECochG-guided CI electrode insertions in EAS candidates.

The purpose of this study is to characterize the safety and efficacy of cochlear promontory stimulation in the short term relief of tinnitus.  

The purpose of this study is to benchmark the feasibility of carotid artery biomechanical analysis and vertebral-basilar Transcranial Doppler (TCD) as markers of vascular involvement in presbyacusis and presbyvestibulopathy.

RATIONALE: Sodium thiosulfate may reduce or prevent hearing loss in young patients receiving cisplatin for cancer. It is not yet known whether sodium thiosulfate is more effective than no additional treatment in preventing hearing loss.

PURPOSE: This randomized phase III trial is studying sodium thiosulfate to see how well it works in preventing hearing loss in young patients receiving cisplatin for newly diagnosed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, osteosarcoma, or other malignancy.