Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss

Overview

About this study

This study aims to demonstrate that the investigational drug AUT00063 is effective and safe in the treatment of age-related hearing loss.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Criteria

  • Be between ages 50-89 years old
  • American-English speaking
  • Have difficulty hearing speech in a noisy environment
  • No recent history of middle ear disease
  • No severe insomnia, major depressive disorders, severe anxiety or post-traumatic stress disorder
  • Not a current or previous user of hearing aids. You are eligible if you were noncompliant and stopped wearing a hearing aid device >6 months earlier for intermittent use or >3 years if you were a full-time consistent user of hearing aid devices
  • Not be dependent on alcohol or drugs
  • Have not participated in another research study within 30-days
  • If female, you must confirm to be non child bearing (post-menopausal for at least 12-months or surgically sterile)
  • If male, you must confirm to use a barrier method (condom)
  • Not be a professional musician
  • No history of important cardiac, endocrine, pulmonary, neurologic, psychiatric, hepatic, renal, hematologic, immunologic, or other major disease deemed clinically significant by the study doctor

While you are in the study, you must:

  • Follow the instructions you are given
  • Come to the study centre for all visits with the study doctor or study staff
  • Answer the telephone at the scheduled date and time for the 2 telephone calls
  • Tell the study doctor or study staff about any changes in your health or the way you feel
  • Tell the study doctor or study staff if you want to stop being in the study at any time
  • Bring your Diary to each visit
  • Not eat or drink anything containing Grapefruit beginning 7-days before Baseline visit (Visit 3, Day 1) until the end of the study
  • Use sun screen if you plan to sunbathe
  • Not use headphones or headsets at high volume
  • Not use hearing aids or devices at any time during the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Douglas Sladen, Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20148446

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