dysphagia

Displaying 11 studies

  • The Role of Therapy for Muscle Tension Dysphagia Scottsdale/Phoenix, AZ

    Muscle tension dysphagia is a novel diagnostic taxonomy describing a subset of patient population with reported dysphagia who exhibit normal oropharyngeal and esophageal swallowing function as evidenced by videofluoroscopic swallow study. These patients also demonstrate abnormal supraglottic muscle tension during laryngoscopy as well as signs of laryngeal hypersensitivity and laryngopharyngeal reflux. Treatment of these patients with Proton Pump Inhibitor (PPI) therapy is a common practice however voice therapy invention targeting the unloading of the supraglottic muscle tension has been shown to be highly effective in symptom resolution per the investigators' clinical experience. The study is designed to answer efficacy of ...

  • A Study of the Quality of Life Before and After Functional Laryngectomy for Patients with End-stage Dysphagia Scottsdale/Phoenix, AZ

    The purpose of this study is to evaluate the quality of life before and after functional laryngectomy for patients with end-stage dysphagia.

  • A Study of Swallowing Problems and Aspiration Risks in Elderly Patients with Cervical Spine Fractures Rochester, MN

    The purpose of this study is to determine the incidence of swallowing disorders and the risk for aspiration in elderly patients who have cervical spine fractures.

  • EndoMAXX EVT Compared to EndoMAXX Rochester, MN

    This is a prospective, single blinded, randomized study of EndoMAXX EVT Fully Covered Esophageal Stent with Valve for the treatment of malignant strictures of the lower esophagus. The purpose of this study is to evaluate improvement of dysphagia due to esophageal stricture with EndoMAXX EVT Fully Covered Esophageal Stent with Valve (investigational device) compared to the EndoMAXX Fully Covered Esophageal Stent (reference device).

  • Trial of Montelukast in Eosinophilic Esophagitis Rochester, MN

    Evaluate clinical effectiveness of oral montelukast compared to placebo on prevention of dysphagia and food impaction in patients with EE.

    Also evaluate tolerance and safety of oral montelukast in treatment of EE.

  • A Study of Budesonide Suspension in Adolescents and Adults with Eosinophilic Esophagitis Measuring Histologic Response and Decreased Dysphagia Rochester, MN

    A study of the effectiveness of oral Budesonide suspension in adolescents and adults with eosinophilic esophagitis measuring the histologic response and determining if any decrease in difficult swallowing is achieved.

  • [Impedance Measurement for Non-Erosive Reflux Disease Rochester, MN

    This study is being done to determine if people with and without GERD or trouble swallowing have increased esophageal mucosa impedance (food getting into the esophageal tissue).

  • A Study To Examine Quality of Life Assessment in Patients Receiving Cryotherapy for Palliation of Dysphagia in Unresectable Esophageal or Gastroesophageal Junctional Cancer Scottsdale/Phoenix, AZ

    The purpose of this study is to determine the effect of endoscopic cryoablation for lessening the effects of dysphagia on the quality of life (QOL) of patients with unresectable esophageal or gastroesophageal junctional cancer.

  • Efficacy of Electrical Stimulation for Dysphagia in Head & Neck Cancer Patients Scottsdale/Phoenix, AZ; Rochester, MN

    The purpose of the investigation is to learn whether intense swallowing exercise or intense swallowing exercise coupled with electrical stimulation (E-Stim) helps patients who had head/neck cancer and currently have dysphagia swallow better.

  • Radiation Therapy with or without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer Jacksonville, FL; Rochester, MN; La Crosse, WI; Albert Lea, MN; Mankato, MN

    RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective when given alone or together ...

  • A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Jacksonville, FL

    This is a multi-center, open-label, Phase Ib dose escalation / Phase II study in recurrent or metastatic head and neck squamous cell carcinoma (RM HNSCC) patients considered to be resistant, ineligible or intolerant to platinum-based chemotherapy. The first aim of the Phase Ib is to determine the Maximum Tolerated Dose(s) (MTD(s)) and/or the Recommended Phase II Dose(s) (RP2D(s)) for BYL719 in combination with cetuximab This part will include two different arms using two different administration methods of BYL719 tablets together with cetuximab as recommended by the label: Arm A - whole tablets will be administered to patients able to swallow ...

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